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Literature summary for 2.7.11.15 extracted from

  • Vinge, L.E.; von Lueder, T.G.; Aasum, E.; Qvigstad, E.; Gravning, J.A.; How, O.J.; Edvardsen, T.; Bj?rnerheim, R.; Ahmed, M.S.; Mikkelsen, B.W.; Oie, E.; Attramadal, T.; Skomedal, T.; Smiseth, O.A.; Koch, W.J.; Larsen, T.S.; Attramadal, H.
    Cardiac-restricted expression of the carboxyl-terminal fragment of GRK3 Uncovers Distinct Functions of GRK3 in regulation of cardiac contractility and growth: GRK3 controls cardiac alpha1-adrenergic receptor responsiveness (2008), J. Biol. Chem., 283, 10601-10610.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information construction of transgenic mice with cardiac-restricted expression of a competitive inhibitor of GRK3, i.e. the carboxyl-terminal plasma membrane targeting domain of GRK3 from Rattus norvegicus, show significantly enhanced agonist-stimulated beta1-adrenergic receptor-mediated activation of ERK1/2, but no alterations of cardiac mass or left ventricular dimensions, versus cardiac myocytes from nontransgenic littermate control mice consistent with inhibition of GRK3, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus GRK2 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by their carboxyl-terminal pleckstrin homology domain, overview ?
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 ?
additional information Mus musculus GRK3 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by its carboxyl-terminal pleckstrin homology domain. GRK3 controls cardiac alpha1-adrenergic receptor responsiveness, distinct functions of GRK3 in regulation of cardiac contractility and growth, overview ?
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 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
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 C56BL/6-CBA hybrid mice
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Mus musculus
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 GRK2; C56BL/6-CBA hybrid mice
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Source Tissue

Source Tissue Comment Organism Textmining
cardiac myocyte GRK2 Mus musculus
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cardiac myocyte GRK3 Mus musculus
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heart distribution of GRK2 in mouse myocardial tissue, overview Mus musculus
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heart distribution of GRK3 in mouse myocardial tissue, overview Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GRK2 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by their carboxyl-terminal pleckstrin homology domain, overview Mus musculus ?
-
 ?
additional information GRK3 in cardiac myocytes catalyzes phosphorylation and desensitization of different G protein-coupled receptors through specificity controlled by its carboxyl-terminal pleckstrin homology domain. GRK3 controls cardiac alpha1-adrenergic receptor responsiveness, distinct functions of GRK3 in regulation of cardiac contractility and growth, overview Mus musculus ?
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 ?

Synonyms

Synonyms Comment Organism
GRK2
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 Mus musculus
GRK3
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 Mus musculus