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Literature summary for 2.7.11.15 extracted from

  • Lymperopoulos, A.; Rengo, G.; Funakoshi, H.; Eckhart, A.D.; Koch, W.J.
    Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure (2007), Nat. Med., 13, 315-323.
    View publication on PubMed
Search for more literature for 2.7.11.15

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Mus musculus 5886
-
plasma membrane
-
 Rattus norvegicus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-adrenergic receptor Mus musculus
-
 ADP + phosphorylated beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor Rattus norvegicus
-
 ADP + phosphorylated beta-adrenergic receptor
-
 ?
additional information Mus musculus adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure, adrenal gland-specific GRK2 inhibition reverses alpha2 beta-adrenergic receptor dysregulation in heart failure, resulting in lowered plasma catecholamine levels, improved cardiac beta-adrenergic signaling and function, and increased sympatholytic efficacy of a alpha2 beta-adrenergic agonist ?
-
 ?
additional information Rattus norvegicus adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure, adrenal gland-specific GRK2 inhibition reverses alpha2 beta-adrenergic receptor dysregulation in heart failure, resulting in lowered plasma catecholamine levels, improved cardiac beta-adrenergic signaling and function, and increased sympatholytic efficacy of a alpha2 beta-adrenergic agonist ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 healthy and heart-failure rats
-
Rattus norvegicus
-
 healthy and heart-failure rats
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Mus musculus
-
adrenal gland
-
 Rattus norvegicus
-
chromaffin cell
-
 Mus musculus
-
chromaffin cell
-
 Rattus norvegicus
-
heart
-
 Mus musculus
-
heart
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-adrenergic receptor
-
 Mus musculus ADP + phosphorylated beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor
-
 Rattus norvegicus ADP + phosphorylated beta-adrenergic receptor
-
 ?
additional information adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure, adrenal gland-specific GRK2 inhibition reverses alpha2 beta-adrenergic receptor dysregulation in heart failure, resulting in lowered plasma catecholamine levels, improved cardiac beta-adrenergic signaling and function, and increased sympatholytic efficacy of a alpha2 beta-adrenergic agonist Mus musculus ?
-
 ?
additional information adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure, adrenal gland-specific GRK2 inhibition reverses alpha2 beta-adrenergic receptor dysregulation in heart failure, resulting in lowered plasma catecholamine levels, improved cardiac beta-adrenergic signaling and function, and increased sympatholytic efficacy of a alpha2 beta-adrenergic agonist Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
GRK2
-
 Mus musculus
GRK2
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus
ATP
-
 Rattus norvegicus