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Literature summary for 2.7.11.15 extracted from

  • Ungerer, M.; Kessebohm, K.; Kronsbein, K.; Lohse, M.J.; Richardt, G.
    Activation of beta-adrenergic receptor kinase during myocardial ischemia (1996), Circ. Res., 79, 455-460.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information myocardial ischemia: beta-ARK is activated, rapid induction of beta-ARK 1 activity in membranes, presumably caused by the release of the receptor agonist noradrenaline Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
heparin specific inhibitor, 1 mM/l: almost complete inhibition of rhodopsin phosphorylation Rattus norvegicus
additional information not inhibited by staurosporine Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol cardiac, total cytosolic activity amount to values almost 3times those of membrane activity, during myocardial ischemia the membrane activity of beta-ARK is increased, but the cytosolic activity is not altered Rattus norvegicus 5829
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membrane cardiac, total cytosolic activity amount to values almost 3times those of membrane activity, during myocardial ischemia the membrane activity of beta-ARK is increased, but the cytosolic activity is not altered Rattus norvegicus 16020
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-adrenergic receptor Rattus norvegicus specifically phosphorylates and inactivates beta-AR after stimulation by receptor agonists, facilitating the binding of the inhibitor protein beta-arrestin to the receptor, during myocardial ischemia the membrane activity of beta-ARK is increased ADP + phospho-beta-adrenergic receptor
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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 male Wistar rats
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Rattus norvegicus
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 beta-ARK 1
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Source Tissue

Source Tissue Comment Organism Textmining
heart during myocardial ischemia the membrane activity of beta-ARK is increased Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Rattus norvegicus ADP + phospho-beta-adrenergic receptor
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 ?
ATP + beta-adrenergic receptor specifically phosphorylates and inactivates beta-AR after stimulation by receptor agonists, facilitating the binding of the inhibitor protein beta-arrestin to the receptor, during myocardial ischemia the membrane activity of beta-ARK is increased Rattus norvegicus ADP + phospho-beta-adrenergic receptor
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 ?
ATP + rhodopsin light-dependent, actual substrate: light-bleached rhodopsin Rattus norvegicus ADP + phosphorhodopsin
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 ?
ATP + rhodopsin in form of bovine rod outer segments Rattus norvegicus ADP + phosphorhodopsin
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 ?

Cofactor

Cofactor Comment Organism Structure
ATP
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 Rattus norvegicus