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Literature summary for 2.7.11.15 extracted from
- The basal subcellular distribution of beta-adrenergic receptor kinase is independent of G-protein betagamma subunits (1997), FEBS Lett., 409, 24-28.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| beta-ARK 1 is stably overexpressed in HEK-293 cells | Bos taurus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Bos taurus | 5829 | - |
| membrane | microsomal and plasma membrane, anchoring of beta-ARK to cellular membranes under basal conditions is independent of the availability of heterotrimeric G protein subunits, additional anchoring mechanisms, Gbetagamma subunits may play a role in agonist-mediated targeting of beta-ARK to the membrane in intact cells | Bos taurus | 16020 | - |
| microsome | microsomal membranes | Bos taurus | - |
- |
| additional information | subcellular distribution of beta-ARK 1 | Bos taurus | - |
- |
| plasma membrane | - |
Bos taurus | 5886 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
Western blot analysis | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Bos taurus | beta-ARK 1 is a key regulatory enzyme involved in the regulation of G protein-coupled receptors which associate with microsomal and plasma membranes | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
beta-ARK 1 | - |
| Bos taurus | - |
enzyme exists in 2 subtypes: beta-ARK 1 and beta-ARK 2 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + beta-adrenergic receptor | - |
Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
| additional information | beta-ARK 1 is a key regulatory enzyme involved in the regulation of G protein-coupled receptors which associate with microsomal and plasma membranes | Bos taurus | ? | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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