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Literature summary for 2.7.11.15 extracted from

  • Benovic, J.L.; Regan, J.W.; Matsui, H.; Mayor, F.; Cotecchia, S.; Leeb-Lundberg, L.M.F.; Caron, M.G.; Lefkowitz, R.J.
    Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase (1987), J. Biol. Chem., 262, 17251-17253.
    View publication on PubMed
Search for more literature for 2.7.11.15

Activating Compound

Activating Compound Comment Organism Structure
(-)-Epinephrine requirement, agonist, alpha2-adrenergic receptor as substrate Bos taurus
isoproterenol requirement, beta-agonist, beta-adrenergic receptor as substrate Bos taurus
additional information alpha2-AR phosphorylation is not stimulated by isoproterenol Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
alpha2-adrenergic antagonist co-incubation completely blocks phosphorylation of alpha2-adrenergic receptor Bos taurus
additional information alprenolol is no inhibitor with alpha2-adrenergic receptor as substrate Bos taurus
Yohimbine alpha2-adrenergic antagonist, co-incubation completely blocks phosphorylation of alpha2-adrenergic receptor Bos taurus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ requirement Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + beta-adrenergic receptor Bos taurus desensitization of beta-adrenergic receptor ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor Bos taurus agonist-occupied form of the receptor ADP + phospho-beta-adrenergic receptor
-
 ?
additional information Bos taurus phosphorylates and regulates receptors coupled to either stimulation or inhibition of adenylate cyclase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain cerebral cortex Bos taurus
-
cerebral cortex
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha2-adrenergic receptor dependent on agonist occupancy by (-)-epinephrine, equally effective as beta-adrenergic receptor, incorporation of 7-8 mol phosphate/mol receptor Bos taurus ADP + phospho-alpha2-adrenergic receptor
-
 ?
ATP + alpha2-adrenergic receptor from human platelets Bos taurus ADP + phospho-alpha2-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor incorporation of 7-8 mol phosphate/mol receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor specifically phosphorylates the agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor at a similar rate as alpha2-adrenergic receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor beta-AR from hamster lung Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor desensitization of beta-adrenergic receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + beta-adrenergic receptor agonist-occupied form of the receptor Bos taurus ADP + phospho-beta-adrenergic receptor
-
 ?
ATP + rhodopsin beta-AR is a much better substrate than rhodopsin Bos taurus ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin light-dependent, actual substrate: light-bleached rhodopsin Bos taurus ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin incorporation of 0.15 mol phosphate/mol rhodopsin Bos taurus ADP + phosphorhodopsin
-
 ?
ATP + rhodopsin in form of bovine rod outer segments Bos taurus ADP + phosphorhodopsin
-
 ?
additional information not: alpha1-adrenergic receptor Bos taurus ?
-
 ?
additional information phosphorylates and regulates receptors coupled to either stimulation or inhibition of adenylate cyclase Bos taurus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Bos taurus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Bos taurus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Bos taurus