Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(-)-Epinephrine | requirement, agonist, alpha2-adrenergic receptor as substrate | Bos taurus | |
isoproterenol | requirement, beta-agonist, beta-adrenergic receptor as substrate | Bos taurus | |
additional information | alpha2-AR phosphorylation is not stimulated by isoproterenol | Bos taurus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha2-adrenergic antagonist | co-incubation completely blocks phosphorylation of alpha2-adrenergic receptor | Bos taurus | |
additional information | alprenolol is no inhibitor with alpha2-adrenergic receptor as substrate | Bos taurus | |
Yohimbine | alpha2-adrenergic antagonist, co-incubation completely blocks phosphorylation of alpha2-adrenergic receptor | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement | Bos taurus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + beta-adrenergic receptor | Bos taurus | desensitization of beta-adrenergic receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | Bos taurus | agonist-occupied form of the receptor | ADP + phospho-beta-adrenergic receptor | - |
? | |
additional information | Bos taurus | phosphorylates and regulates receptors coupled to either stimulation or inhibition of adenylate cyclase | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | cerebral cortex | Bos taurus | - |
cerebral cortex | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + alpha2-adrenergic receptor | dependent on agonist occupancy by (-)-epinephrine, equally effective as beta-adrenergic receptor, incorporation of 7-8 mol phosphate/mol receptor | Bos taurus | ADP + phospho-alpha2-adrenergic receptor | - |
? | |
ATP + alpha2-adrenergic receptor | from human platelets | Bos taurus | ADP + phospho-alpha2-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | incorporation of 7-8 mol phosphate/mol receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | specifically phosphorylates the agonist-occupied form of the receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | at a similar rate as alpha2-adrenergic receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | beta-AR from hamster lung | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | desensitization of beta-adrenergic receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + beta-adrenergic receptor | agonist-occupied form of the receptor | Bos taurus | ADP + phospho-beta-adrenergic receptor | - |
? | |
ATP + rhodopsin | beta-AR is a much better substrate than rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | light-dependent, actual substrate: light-bleached rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | incorporation of 0.15 mol phosphate/mol rhodopsin | Bos taurus | ADP + phosphorhodopsin | - |
? | |
ATP + rhodopsin | in form of bovine rod outer segments | Bos taurus | ADP + phosphorhodopsin | - |
? | |
additional information | not: alpha1-adrenergic receptor | Bos taurus | ? | - |
? | |
additional information | phosphorylates and regulates receptors coupled to either stimulation or inhibition of adenylate cyclase | Bos taurus | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Bos taurus |