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Literature summary for 2.7.11.14 extracted from

  • He, Y.; Gao, X.; Goswami, D.; Hou, L.; Pal, K.; Yin, Y.; Zhao, G.; Ernst, O.P.; Griffin, P.; Melcher, K.; Xu, H.E.
    Molecular assembly of rhodopsin with G protein-coupled receptor kinases (2017), Cell Res., 27, 728-747 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
D116R the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
E238A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
E521A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
F122E the mutant shows increased activity compared to the wild type enzyme Homo sapiens
F125E the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
F528E inactive Homo sapiens
G529A the mutant shows increased activity compared to the wild type enzyme Homo sapiens
K120E the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
K219A inactive Homo sapiens
K219R inactive Homo sapiens
K33E the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
K34A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
K38A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
K40C the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
L169A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
L172C the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
L39G inactive Homo sapiens
L41G inactive Homo sapiens
L531E the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
L71A inactive Homo sapiens
P117A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
P42A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
Q118A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
Q176A inactive Homo sapiens
Q74A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
R173A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
R461A the mutant shows wild type activity Homo sapiens
S124L the mutant shows wild type activity Homo sapiens
T212G inactive Homo sapiens
T97G the mutant shows wild type activity Homo sapiens
W177A inactive Homo sapiens
Y170A/Q176A inactive Homo sapiens
Y170A/W177A inactive Homo sapiens
Y255A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens
Y35A the mutant shows reduced activity compared to the wild type enzyme Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
paroxetine
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + rhodopsin Homo sapiens
-
ADP + phosphorhodopsin
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q15835
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + rhodopsin
-
Homo sapiens ADP + phosphorhodopsin
-
?

Synonyms

Synonyms Comment Organism
G protein-coupled receptor kinase
-
Homo sapiens
GRK1 isoform Homo sapiens