Cloned (Comment) | Organism |
---|---|
expressed in Sf9 insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D116R | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
E238A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
E521A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
F122E | the mutant shows increased activity compared to the wild type enzyme | Homo sapiens |
F125E | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
F528E | inactive | Homo sapiens |
G529A | the mutant shows increased activity compared to the wild type enzyme | Homo sapiens |
K120E | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
K219A | inactive | Homo sapiens |
K219R | inactive | Homo sapiens |
K33E | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
K34A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
K38A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
K40C | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
L169A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
L172C | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
L39G | inactive | Homo sapiens |
L41G | inactive | Homo sapiens |
L531E | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
L71A | inactive | Homo sapiens |
P117A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
P42A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
Q118A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
Q176A | inactive | Homo sapiens |
Q74A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
R173A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
R461A | the mutant shows wild type activity | Homo sapiens |
S124L | the mutant shows wild type activity | Homo sapiens |
T212G | inactive | Homo sapiens |
T97G | the mutant shows wild type activity | Homo sapiens |
W177A | inactive | Homo sapiens |
Y170A/Q176A | inactive | Homo sapiens |
Y170A/W177A | inactive | Homo sapiens |
Y255A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
Y35A | the mutant shows reduced activity compared to the wild type enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
paroxetine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + rhodopsin | Homo sapiens | - |
ADP + phosphorhodopsin | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15835 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + rhodopsin | - |
Homo sapiens | ADP + phosphorhodopsin | - |
? |
Synonyms | Comment | Organism |
---|---|---|
G protein-coupled receptor kinase | - |
Homo sapiens |
GRK1 | isoform | Homo sapiens |