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Literature summary for 2.7.11.14 extracted from
- Amino acid residues in GRK1/GRK7 responsible for interaction with S-modulin/recoverin (2008), Photochem. Photobiol., 84, 823-830.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GRK1 peptides | bovine commercial preparation, inhibition analysis of enzyme binding to S-modulin, overview | Lithobates catesbeianus | |
| S-modulin/recoverin | recombinant myristoylated S-modulin overexpressed in Escherichia coli, GRK1 activity is inhibited by binding of the Ca2+-bound form of S-modulin/recoverin, determination of the binding site by peptide mapping, binding involves Leu6, Asn12, and Tyr15, mutation of these residues reduces the inhibition significantly, inhibition mechanism, overview | Lithobates catesbeianus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Lithobates catesbeianus | 16020 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | GRK1 activity is inhibited by binding of the Ca2+-bound form of S-modulin/recoverin | Lithobates catesbeianus |  |
| Mg2+ | - |
Lithobates catesbeianus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + rhodopsin | Lithobates catesbeianus | GRK1 is a visual pigment kinase in rods and is essential for inactivation of light-activated rhodopsin | ADP + phosphorhodopsin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Lithobates catesbeianus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retinal rod | - |
Lithobates catesbeianus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + rhodopsin | - |
Lithobates catesbeianus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | GRK1 is a visual pigment kinase in rods and is essential for inactivation of light-activated rhodopsin | Lithobates catesbeianus | ADP + phosphorhodopsin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| GRK1 | - |
Lithobates catesbeianus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at room temperature | Lithobates catesbeianus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Lithobates catesbeianus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Lithobates catesbeianus | |
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Release 2023.1 (January 2023)
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