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Literature summary for 2.7.11.14 extracted from
- GRK1 and GRK7: unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones (2006), J. Neurochem., 98, 824-837.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isozyme GRK1 1A, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression of GRK proteins in HEK-293S cells | Danio rerio |
| isozyme GRK1B, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression of GRK proteins in HEK-293S cells | Danio rerio |
| isozyme GRK7 71, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293S cells | Danio rerio |
| isozyme GRK72, DNA and amino acid sequence determination and analysis, phylogenetic analysis, expression in HEK-293S cells | Danio rerio |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Danio rerio |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + opsin | Danio rerio | the enzyme is involved in the opsin deactivation process, GRK subtypes play a role in phosphorylating non-visual opsins in the particular extraretinal tissues | ADP + phosphoopsin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Danio rerio | Q1XHL7 | isozyme GRK7-2; gene grk7b, isozyme GRK 72 | - |
| Danio rerio | Q1XHM0 | isozyme GRK1A; isozyme GRK1A | - |
| Danio rerio | Q49HM9 | isozyme GRK7-1; gene grk7a, isozyme GRK7 71 | - |
| Danio rerio | Q49HN0 | isozyme GRK1B; isozyme GRK1B | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | GRK7-2, almost exclusively in the brain | Danio rerio | - |
| cone | - |
Danio rerio | - |
| eye | - |
Danio rerio | - |
| additional information | isozyme expression analysis, overview | Danio rerio | - |
| pineal gland | GRK1B and GRK7-2 are the dominant subtypes | Danio rerio | - |
| retina | rods and cones | Danio rerio | - |
| retinal rod | - |
Danio rerio | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
quantitative determination of GRK mRNA and protein in the eye, initial reaction velocities at 25°C and 30°C, overview | Danio rerio |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + opsin | - |
Danio rerio | ADP + phosphoopsin | - |
? | |
| ATP + opsin | the enzyme is involved in the opsin deactivation process, GRK subtypes play a role in phosphorylating non-visual opsins in the particular extraretinal tissues | Danio rerio | ADP + phosphoopsin | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| G protein-coupled receptor kinase | - |
Danio rerio |
| GRK1 | - |
Danio rerio |
| GRK7 | - |
Danio rerio |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | 30 | assay at | Danio rerio |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Danio rerio |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Danio rerio | |
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