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Literature summary for 2.7.11.14 extracted from
- Recoverin and rhodopsin kinase (2002), Adv. Exp. Med. Biol., 514, 101-107.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | Oguchi disease patients suffering from congenital stationary night blindness have defective RK or arrestin genes | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | - |
Homo sapiens |
| additional information | RK knockout mice | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| recoverin | Ca2+-dependent inhibition | Mus musculus |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Mus musculus |  |
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + rhodopsin | Homo sapiens | - |
ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | Mus musculus | initiation of deactivation of photoexcited visual pigments in rod and cone photoreceptors, recoverin is a Ca2+-dependent negative regulator of RK in vertebrate phototransduction | ADP + phosphorhodopsin | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| eye | retina | Mus musculus | - |
| eye | retina | Homo sapiens | - |
| retina | in rod and cone photoreceptors | Mus musculus | - |
| retina | in rod and cone photoreceptors | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + rhodopsin | - |
Homo sapiens | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | light-dependent phosphorylation | Mus musculus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | phosphorylates serine and threonine residues in the carboxy-terminal region of opsin peptide | Mus musculus | ADP + phosphorhodopsin | - |
? | |
| ATP + rhodopsin | initiation of deactivation of photoexcited visual pigments in rod and cone photoreceptors, recoverin is a Ca2+-dependent negative regulator of RK in vertebrate phototransduction | Mus musculus | ADP + phosphorhodopsin | - |
? | |
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Release 2023.1 (January 2023)
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