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Literature summary for 2.7.11.13 extracted from

  • Qvit, N.; Disatnik, M.H.; Sho, E.; Mochly-Rosen, D.
    Selective phosphorylation inhibitor of delta protein kinase C-pyruvate dehydrogenase kinase protein-protein interactions Application for myocardial injury in vivo (2016), J. Am. Chem. Soc., 138, 7626-7635 .
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
ALSTER psi pyruvate dehydrogenase kinase peptide, selective inhibitor of deltaPKC-mediated pyruvate dehydrogenase kinase phosphorylation Rattus norvegicus
YGRKKRRQRRR-GSG-ALSTER psi pyruvate dehydrogenase kinase 1 peptide, inhibits the phosphorylation of pyruvate dehydrogenase kinase but not the phosphorylation of HSP, MARCKS, STAT, GAPDH, and troponin I Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + pyruvate dehydrogenase kinase Rattus norvegicus
-
 ADP + phosphorylated pyruvate dehydrogenase kinase
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P09215
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + pyruvate dehydrogenase kinase
-
 Rattus norvegicus ADP + phosphorylated pyruvate dehydrogenase kinase
-
 ?

Synonyms

Synonyms Comment Organism
delta protein kinase C
-
 Rattus norvegicus
deltaPKC
-
 Rattus norvegicus

General Information

General Information Comment Organism
physiological function pyruvate dehydrogenase kinase phosphorylation alone is critical for delta protein kinase C mediated injury by heart attack Rattus norvegicus