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Literature summary for 2.7.11.13 extracted from

  • Lee, A.
    The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages (2011), PLoS ONE, 6, e25580.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
CSF-1 CSF-1 increases PKCgamma Thr 410 phosphorylation and kinase activity in 32D.R cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
bisindolylmaleimide I
-
 Homo sapiens
Gö 6983
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
myeloid cell line myeloid progenitor cell line 32D.R Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + a protein
-
 Homo sapiens ADP + a phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
PKC-zeta
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0025
-
 pH not specified in the publication, 30°C Homo sapiens Gö 6983
0.0075
-
 pH not specified in the publication, 30°C Homo sapiens bisindolylmaleimide I

General Information

General Information Comment Organism
physiological function PKCzeta kinase inhibition reduces CSF-1 supported mitogenesis in 32D.R cells. Its overexpression increases CSF-1 mitogenic responsiveness. PKCzeta's promotion of mitogenic signaling in 32D.R cells is independent of NF-kB. In primary murine bone marrow derived macrophages (BMMs), PKCzeta inhibition has a more modest effect on CSF-1 dependent mitogenesis, and, pan-PKC inhibition has a paradoxically enhancing effect on MEK-Erk phosphorylation. Thus the importance of PKCzeta in the control of CSF-1 mediated MEKErk activity and mitogenesis depends on differentiation stage Homo sapiens