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Literature summary for 2.7.11.13 extracted from

  • Liu, Y.; Song, R.; Gao, Y.; Li, Y.; Wang, S.; Liu, H.Y.; Wang, Y.; Hu, Y.H.; Shu, H.B.
    Protein kinase C-delta negatively regulates T cell receptor-induced NF-?B activation by inhibiting the assembly of CARMA1 signalosome (2012), J. Biol. Chem., 287, 20081-20087.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information using a kinase dead mutant it is shown that the kinase activity of PKCdelta is not required for its inhibitory role in TCR-induced NF-kappaB activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens PKCdelta associates with caspase recruitment domain-containing membrane-associated guanylate kinase 1 (CARMA1) ?
-
 ?
additional information Homo sapiens PKCdelta interacts with mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) and TRAF6 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PKCdelta associates with caspase recruitment domain-containing membrane-associated guanylate kinase 1 (CARMA1) Homo sapiens ?
-
 ?
additional information PKCdelta interacts with mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) and TRAF6 Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PKCdelta
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of PKCdelta accelerates T-cell receptor-induced NF-kappaB activation and IL-2 secretion, suggesting an inhibitory role of PKCdelta in T-cell receptor-mediated NF-kappaB activation. PKCdelta inhibits T-cell receptor-induced NF-kappaB activation by steric hindrance of recruiting TRAF6 to CARMA1 signalosome Homo sapiens
malfunction overexpression of PKCdelta inhibits CARMA1-mediated NF-kappaB activation Homo sapiens