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Literature summary for 2.7.11.13 extracted from

  • Titchenell, P.M.; Hollis Showalter, H.D.; Pons, J.F.; Barber, A.J.; Jin, Y.; Antonetti, D.A.
    Synthesis and structure-activity relationships of 2-amino-3-carboxy-4-phenylthiophenes as novel atypical protein kinase C inhibitors (2013), Bioorg. Med. Chem. Lett., 23, 3034-3038.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.13

Inhibitors

Inhibitors Comment Organism Structure
1-methoxypropan-2-yl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 49% Homo sapiens
2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carbonitrile 0.03 mM, inhibition: 87% Homo sapiens
2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylic acid 0.03 mM, inhibition: 65% Homo sapiens
2-fluorobenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
2-methoxyethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 57% Homo sapiens
2-methylbenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 64% Homo sapiens
3-cyanobenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 70% Homo sapiens
3-methoxybenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
3-methylbenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 67% Homo sapiens
4-cyanobenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 10% Homo sapiens
4-fluorobenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 2% Homo sapiens
4-methylbenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 50% Homo sapiens
benzyl 2-amino-4-(1,3-benzodioxol-5-yl)thiophene-3-carboxylate 0.03 mM, inhibition: 85% Homo sapiens
benzyl 2-amino-4-(2-fluoro-4-methoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 78% Homo sapiens
benzyl 2-amino-4-(2-fluorophenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 57% Homo sapiens
benzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
benzyl 2-amino-4-(3-cyanophenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 25% Homo sapiens
benzyl 2-amino-4-(3-fluorophenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 53% Homo sapiens
benzyl 2-amino-4-(3-methoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 57% Homo sapiens
benzyl 2-amino-4-(3-methylphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 68% Homo sapiens
benzyl 2-amino-4-(4-methoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 86% Homo sapiens
benzyl 2-amino-4-(4-methylphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 60% Homo sapiens
benzyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate 0.03 mM, inhibition: 29% Homo sapiens
benzyl 2-amino-4-[4-(trifluoromethyl)phenyl]thiophene-3-carboxylate 0.03 mM, inhibition: 21% Homo sapiens
ethyl 2-(carbamoylamino)-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 14% Homo sapiens
ethyl 2-amino-4-(1,3-benzodioxol-5-yl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
ethyl 2-amino-4-(2-fluoro-4-methoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
ethyl 2-amino-4-(2-fluorophenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 62% Homo sapiens
ethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
ethyl 2-amino-4-(3-cyanophenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 32% Homo sapiens
ethyl 2-amino-4-(3-fluoro-4-methoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
ethyl 2-amino-4-(3-fluorophenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 38% Homo sapiens
ethyl 2-amino-4-(3-methoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 82% Homo sapiens
ethyl 2-amino-4-(3-methylphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 77% Homo sapiens
ethyl 2-amino-4-(4-aminophenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
ethyl 2-amino-4-(4-methoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
ethyl 2-amino-4-(4-methylphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 80% Homo sapiens
ethyl 2-amino-4-[3-(trifluoromethyl)phenyl]thiophene-3-carboxylate 0.03 mM, inhibition: 16%; 0.03 mM, inhibition: 30% Homo sapiens
ethyl 2-amino-4-[4-(dimethylamino)phenyl]thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
ethyl 4-(3,4-dimethoxyphenyl)-2-(dimethylamino)thiophene-3-carboxylate 0.03 mM, inhibition: 60% Homo sapiens
ethyl 4-(3,4-dimethoxyphenyl)-2-(methylamino)thiophene-3-carboxylate 0.03 mM, inhibition: 32% Homo sapiens
ethyl 4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 3% Homo sapiens
phenyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 48% Homo sapiens
propan-2-yl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 100% Homo sapiens
pyridin-4-ylmethyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate 0.03 mM, inhibition: 53% Homo sapiens
[2-amino-4-(3,4-dimethoxyphenyl)thiophen-3-yl][(benzylamino)oxy]methanone 0.03 mM, inhibition: 43% Homo sapiens
[2-amino-4-(3,4-dimethoxyphenyl)thiophen-3-yl][(ethylamino)oxy]methanone 0.03 mM, inhibition: 50% Homo sapiens
[2-amino-4-(3,4-dimethoxyphenyl)thiophen-3-yl]{[(2-methoxyethyl)amino]oxy}methanone 0.03 mM, inhibition: 55% Homo sapiens
[2-amino-4-(3,4-dimethoxyphenyl)thiophen-3-yl]{[(pyridin-4-ylmethyl)amino]oxy}methanone 0.03 mM, inhibition: 3% Homo sapiens
{3-[5-amino-4-(ethoxycarbonyl)thiophen-3-yl]phenyl}carbamate 0.03 mM, inhibition: 89% Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
aPKCzeta
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.001
-
 pH and temperature not specified in the publication Homo sapiens ethyl 2-amino-4-(4-aminophenyl)thiophene-3-carboxylate
0.002
-
 pH and temperature not specified in the publication Homo sapiens ethyl 2-amino-4-(4-methoxyphenyl)thiophene-3-carboxylate
0.002
-
 pH and temperature not specified in the publication Homo sapiens ethyl 2-amino-4-(1,3-benzodioxol-5-yl)thiophene-3-carboxylate
0.004
-
 pH and temperature not specified in the publication Homo sapiens ethyl 2-amino-4-(2-fluoro-4-methoxyphenyl)thiophene-3-carboxylate
0.005
-
 pH and temperature not specified in the publication Homo sapiens 3-methoxybenzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
0.006
-
 pH and temperature not specified in the publication Homo sapiens propan-2-yl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate
0.006
-
 pH and temperature not specified in the publication Homo sapiens benzyl 2-amino-4-(3,4-dimethoxyphenyl)thiophene-3-carboxylate