Literature summary for 2.7.11.13 extracted from

Bruns, A.F.; Herbert, S.P.; Odell, A.F.; Jopling, H.M.; Hooper, N.M.; Zachary, I.C.; Walker, J.H.; Ponnambalam, S.
Ligand-stimulated VEGFR2 signaling is regulated by co-ordinated trafficking and proteolysis (2010), Traffic, 11, 161-174.

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Activating Compound

Activating Compound	Comment	Organism	Structure
phorbol 12-myristate 13-acetate	-	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	PKC activation alone can target VEGFR2 for limited proteolysis, while PKC inhibition delays VEGFR2 processing but does not block this step	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HUVEC cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + vascular endothelial growth factor receptor 2	phosphorylation at Ser1188 and Ser 1191	Homo sapiens	ADP + phosphorylated vascular endothelial growth factor receptor 2	-	?
additional information	PKC activation alone can target VEGFR2 for limited proteolysis, while PKC inhibition delays VEGFR2 processing but does not block this step	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PKC	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)