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Literature summary for 2.7.11.13 extracted from
- Increased potassium conductance of brain mitochondria induces resistance to permeability transition by enhancing matrix volume (2010), J. Biol. Chem., 285, 741-750.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| hydrogen peroxide | - |
Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ro318220 | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrial membrane | - |
Rattus norvegicus | 31966 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | PKCepsilon associates with and inhibits activation of the mitochondrial permeability transition pore complex | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKCepsilon | isoform | Rattus norvegicus |
| protein kinase epsilon | isoform | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Rattus norvegicus | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Rattus norvegicus | mitochondrial reactive oxygen species production activates PKCepsilon | up |
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Release 2023.1 (January 2023)
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