Activating Compound | Comment | Organism | Structure |
---|---|---|---|
1,2-diacyl-sn-glycerol | - |
Homo sapiens | |
12-O-Tetradecanoylphorbol 13-acetate | - |
Homo sapiens | |
phosphatidylserine | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | activates | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + inhibitory killer cell Ig-like receptor | Homo sapiens | the enzyme regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells, KIR negatively regulate NK cell cytotoxicity by activating Src homology 2 domain-containing protein tyrsine phospatase 1 and 2, overview | ADP + phosphorylated inhibitory killer cell Ig-like receptor | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
NK-92 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + inhibitory killer cell Ig-like receptor | the enzyme regulates expression and function of inhibitory killer cell Ig-like receptors in NK cells, KIR negatively regulate NK cell cytotoxicity by activating Src homology 2 domain-containing protein tyrsine phospatase 1 and 2, overview | Homo sapiens | ADP + phosphorylated inhibitory killer cell Ig-like receptor | - |
? | |
ATP + inhibitory killer cell Ig-like receptor | phosphorylation of the cytoplasmic tail, mutational analysis of kinase phosphorylation sites, e.g. Ser394, activity with substrate mutants, overview | Homo sapiens | ADP + phosphorylated inhibitory killer cell Ig-like receptor | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKC | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |