Activating Compound | Comment | Organism | Structure |
---|---|---|---|
12-O-Tetradecanoylphorbol 13-acetate | activates PKC | Rattus norvegicus | |
curcumin | inhibits or activates PKC dependent on Ca2+ and the presence of membranes or phosphatidylserine, respectively, in presence of phosphatidylserine curcumin activates PKC, in presence of membranes with phosphatidylserine the enzyme is inhibited, Ca2+ competes with curcumin at the regulatory domainbinding site, overview, effects on different isozymes, overview | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
curcumin | inhibits or activates PKC dependent on Ca2+ and the presence of membranes or phosphatidylserine, respectively, in presence of phosphatidylserine curcumin activates PKC, in presence of membranes with phosphatidylserine the enzyme is inhibited, Ca2+ competes with curcumin at the regulatory domainbinding site, overview, effects on different isozymes, overview | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | stimulates the enzyme, binds to the regulatory domain of PKC, competes with effector curcumin, overview, no effect by cysteine | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Na,K-ATPase | Rattus norvegicus | - |
ADP + phosphorylated Na,K-ATPase | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Ca2+-dependent isozyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + histone | in presence of absence of phosphatidylserine-containing liposomes | Rattus norvegicus | ADP + phosphorylated histone | - |
? | |
ATP + Na,K-ATPase | - |
Rattus norvegicus | ADP + phosphorylated Na,K-ATPase | - |
? | |
ATP + Na,K-ATPase | substrate in membrane vesicles from the rectal gland of the spiny dog fish Squalus acanthias | Rattus norvegicus | ADP + phosphorylated Na,K-ATPase | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
24 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Rattus norvegicus |