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Literature summary for 2.7.11.13 extracted from

  • Mahmmoud, Y.A.
    Modulation of protein kinase C by curcumin; inhibition and activation switched by calcium ions (2007), Br. J. Pharmacol., 150, 200-208.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
12-O-Tetradecanoylphorbol 13-acetate activates PKC Rattus norvegicus
curcumin inhibits or activates PKC dependent on Ca2+ and the presence of membranes or phosphatidylserine, respectively, in presence of phosphatidylserine curcumin activates PKC, in presence of membranes with phosphatidylserine the enzyme is inhibited, Ca2+ competes with curcumin at the regulatory domainbinding site, overview, effects on different isozymes, overview Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
curcumin inhibits or activates PKC dependent on Ca2+ and the presence of membranes or phosphatidylserine, respectively, in presence of phosphatidylserine curcumin activates PKC, in presence of membranes with phosphatidylserine the enzyme is inhibited, Ca2+ competes with curcumin at the regulatory domainbinding site, overview, effects on different isozymes, overview Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ stimulates the enzyme, binds to the regulatory domain of PKC, competes with effector curcumin, overview, no effect by cysteine Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Na,K-ATPase Rattus norvegicus
-
ADP + phosphorylated Na,K-ATPase
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Ca2+-dependent isozyme
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + histone in presence of absence of phosphatidylserine-containing liposomes Rattus norvegicus ADP + phosphorylated histone
-
?
ATP + Na,K-ATPase
-
Rattus norvegicus ADP + phosphorylated Na,K-ATPase
-
?
ATP + Na,K-ATPase substrate in membrane vesicles from the rectal gland of the spiny dog fish Squalus acanthias Rattus norvegicus ADP + phosphorylated Na,K-ATPase
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
24
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Rattus norvegicus