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Literature summary for 2.7.11.13 extracted from

  • Gu, J.L.; Lu, W.; Xia, C.; Wu, X.; Liu, M.
    Regulation of hematopoietic-specific G-protein Galpha15 and Galpha16 by protein kinase C (2003), J. Cell. Biochem., 88, 1101-1111.
    View publication on PubMed
Search for more literature for 2.7.11.13

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylserine-diolein
-
 Rattus norvegicus

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Rattus norvegicus
Mg2+
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 isozyme pKCalpha
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
commercial preparation purified PKC from brain Rattus norvegicus
-
hematopoietic cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + hematopoietic-specific G-protein Galpha15 recombinant substrate expressed in COS-7 cells, phosphorylation at Ser334, mutant G-protein Galpha15 S334A is inactive as substrate for PKC Rattus norvegicus ADP + phosphorylated hematopoietic-specific G-protein Galpha15
-
 ?
ATP + hematopoietic-specific G-protein Galpha15 peptide the PKC phosphorylation site peptide sequence RKGSR includes Ser334 Rattus norvegicus ADP + phosphorylated hematopoietic-specific G-protein Galpha15 peptide
-
 ?
ATP + hematopoietic-specific G-protein Galpha16 substrate from HL-60 cells, phosphorylation at Ser336, mutant G-protein Galpha16 S336A is inactive as substrate for PKC Rattus norvegicus ADP + phosphorylated hematopoietic-specific G-protein Galpha16
-
 ?
ATP + hematopoietic-specific G-protein Galpha16 peptide the PKC phosphorylation site peptide sequence KKGARSRR includes Ser336 Rattus norvegicus ADP + phosphorylated hematopoietic-specific G-protein Galpha16 peptide
-
 ?
additional information phosphorylation by PKC is involved in regulation of hematopoietic-specific G-protein Galpha15 and Galpha16, deletion of the PKC phosphorylation site leads to inhibition of receptor-coupled phospholipase C activation Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
PKC
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus