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Literature summary for 2.7.11.13 extracted from

  • Ranganathan, S.; Liu, C.X.; Migliorini, M.M.; Von Arnim, C.A.; Peltan, I.D.; Mikhailenko, I.; Hyman, B.T.; Strickland, D.K.
    Serine and threonine phosphorylation of the low density lipoprotein receptor-related protein by protein kinase Calpha regulates endocytosis and association with adaptor molecules (2004), J. Biol. Chem., 279, 40536-40544.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
K-252a strong inhibition Homo sapiens
additional information no inhibition by genistein and H-89 Homo sapiens
Ro-32-0432 strong inhibition Rattus norvegicus
staurosporine strong inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [low density lipoprotein receptor-related protein] Homo sapiens involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
?
ATP + [low density lipoprotein receptor-related protein] Rattus norvegicus involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant PKCalpha Homo sapiens
-
fibroblast
-
Homo sapiens
-
lung
-
Rattus norvegicus
-
smooth muscle cell pulmonary cell line Rattus norvegicus
-
WI-38 cell fibroblast cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [low density lipoprotein receptor-related protein] involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP Homo sapiens ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
?
ATP + [low density lipoprotein receptor-related protein] involved in regulation of endocytosis and association with adaptor molecules, e.g. Shc, Dab1, or CED-6/GULP Rattus norvegicus ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
?
ATP + [low density lipoprotein receptor-related protein] i.e. LPR, phosphorylation of cytoplasmic domain residues T63, T16, S3, S73, S76, and S79 Homo sapiens ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
?
ATP + [low density lipoprotein receptor-related protein] i.e. LPR, phosphorylation of cytoplasmic domain serine and threonine residues Rattus norvegicus ADP + phosphorylated [low density lipoprotein receptor-related protein]
-
?
additional information activity with wild-type and mutant substrate low density lipoprotein receptor-related protein, overview Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PKCalpha
-
Homo sapiens
PKCalpha
-
Rattus norvegicus
protein kinase Calpha
-
Homo sapiens
protein kinase Calpha
-
Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens
37
-
assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens
ATP
-
Rattus norvegicus