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Literature summary for 2.7.11.12 extracted from

  • Wilson, T.J.; Zamler, D.B.; Doherty, R.; Castro, M.G.; Lowenstein, P.R.
    Reversibility of glioma stem cells phenotypes explains their complex in vitro and in vivo behavior Discovery of a novel neurosphere-specific enzyme, cGMP-dependent protein kinase 1, using the genomic landscape of human glioma stem cells as a discovery tool (2016), Oncotarget, 7, 63020-63041 .
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
8-Br-PET-cGMP highly specific activator of both the A and B isoforms of cGMP-dependent protein kinase I Homo sapiens
cGMP
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GluA1 protein Homo sapiens
-
 ADP + GluA1 phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell
-
 Homo sapiens
-
HF-2303 cell
-
 Homo sapiens
-
IN-2045 cell
-
 Homo sapiens
-
IN-859 cell
-
 Homo sapiens
-
MGG-8 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GluA1 protein
-
 Homo sapiens ADP + GluA1 phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase 1
-
 Homo sapiens
PRKG1
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function stimulation of enzyme activity preferentially reduces cell viability in the sphere phenotype of glioblastoma cells Homo sapiens