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Literature summary for 2.7.11.12 extracted from

  • Campbell, J.C.; VanSchouwen, B.; Lorenz, R.; Sankaran, B.; Herberg, F.W.; Melacini, G.; Kim, C.
    Crystal structure of cGMP-dependent protein kinase Ib cyclic nucleotide-binding-B domain Rp-cGMPS complex reveals an apo-like, inactive conformation (2017), FEBS Lett., 591, 221-230 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
cGMP activation constant (Ka) of 537 nM Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
cGMP-dependent protein kinase Ib cyclic nucleotide-binding domain, hanging drop vapor diffusion method, using 0.8 M lithium sulfate monohydrate, 0.1 M sodium acetate trihydrate, pH 4.0, 4% (v/v) polyethylene glycol 200 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the R-diastereomer of the phosphorothioate analog of cGMP, Rp-cGMPS, inhibits enzyme isoform PKG I by stabilizing the inactive conformation of cyclic nucleotide-binding domain Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 10 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Kemptide Homo sapiens
-
 ADP + Kemptide phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13976
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Kemptide
-
 Homo sapiens ADP + Kemptide phosphate
-
 ?

Synonyms

Synonyms Comment Organism
cGMP-dependent protein kinase Ib
-
 Homo sapiens
PKG Ibeta
-
 Homo sapiens