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Literature summary for 2.7.11.12 extracted from

  • Incontro, S.; Ciruela, F.; Ziff, E.; Hofmann, F.; Sanchez-Prieto, J.; Torres, M.
    The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells (2013), Biochim. Biophys. Acta, 1833, 1820-1831.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cGMP activation of cGKII by 8-bromo-cGMP enhances the surface expression of GluA1, whereas its inhibition or suppression effectively diminishes the expression of this protein at the cell surface Rattus norvegicus
cGMP cGMP-dependent activation of GKII depends on NO produced by nitric oxide synthase upon NMDA receptor activation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Rattus norvegicus 5886
-
synapse
-
 Rattus norvegicus 45202
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + GluA1 protein Rattus norvegicus phosphorylation at Ser845 by type II cGMP-dependent protein kinase ADP + GluA1 phosphoprotein
-
 ?
ATP + GluA1 protein Rattus norvegicus Wistar phosphorylation at Ser845 by type II cGMP-dependent protein kinase ADP + GluA1 phosphoprotein
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-
Rattus norvegicus Wistar
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-
granule cell
-
 Rattus norvegicus
-
neuronal cell primary Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + GluA1 protein phosphorylation at Ser845 by type II cGMP-dependent protein kinase Rattus norvegicus ADP + GluA1 phosphoprotein
-
 ?
ATP + GluA1 protein phosphorylation at Ser845 by type II cGMP-dependent protein kinase Rattus norvegicus Wistar ADP + GluA1 phosphoprotein
-
 ?

Synonyms

Synonyms Comment Organism
cGKII
-
 Rattus norvegicus
type II cGMP dependent protein kinase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus

Expression

Organism Comment Expression
Rattus norvegicus cGKII silencing by siRNA, with target sequence CUUUCAAGGACAAUAAAUA down

General Information

General Information Comment Organism
physiological function cGMP production activates cGKII and induces the phosphorylation of GluA1, promoting its accumulation in the plasma membrane. Phosphorylation of GluA1 at Ser845 by type II cGMP-dependent protein kinase augments the surface expression of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors at both synaptic and extrasynaptic sites. Activation of cGKII by 8-Br-cGMP enhances the surface expression of GluA1, whereas its inhibition or suppression effectively diminishes the expression of this protein at the cell surface, overview Rattus norvegicus