Literature summary for 2.7.11.12 extracted from

Dou, D.; Zheng, X.; Qin, X.; Qi, H.; Liu, L.; Raj, J.U.; Gao, Y.
Role of cGMP-dependent protein kinase in development of tolerance to nitroglycerine in porcine coronary arteries (2008), Br. J. Pharmacol., 153, 497-507.

Search for more literature for 2.7.11.12

Inhibitors

Inhibitors	Comment	Organism	Structure
2,2'-(hydroxynitrosohydrazono)-bis-ethanamine	24 h incubation with 2,2'-(hydroxynitrosohydrazono)-bis-ethanamine after incubation with cGMP is associated with decreased PKG activity	Sus scrofa
8-bromo-cGMP	-	Sus scrofa
beta-phenyl-1,N2-etheno-8-bromoguanosine-3',5'-cyclic monophosphorothioate	-	Sus scrofa
additional information	superoxide and 8-bromo-cAMP have no effect on PKG activity	Sus scrofa
nitroglycerine	24 h incubation with nitroglycerine after incubation with cGMP is associated with decreased PKG activity, PKG mRNA and protein are downregulated by a 24 h incubation with nitroglycerine at 0.01 mM but not at 0.0001 mM	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
coronary artery	-	Sus scrofa	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + BPDEtide	-	Sus scrofa	ADP + phosphorylated BPDEtide	-	?

Synonyms

Synonyms	Comment	Organism
PKG	-	Sus scrofa

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Sus scrofa
cGMP	dependent	Sus scrofa

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Release 2023.1 (January 2023)