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Literature summary for 2.7.11.12 extracted from

  • Perkins, W.J.; Warner, D.O.; Jones, K.A.
    Prolonged treatment of porcine pulmonary artery with nitric oxide decreases cGMP sensitivity and cGMP-dependent protein kinase specific activity (2008), Am. J. Physiol. Lung Cell Mol. Physiol., 296, L121-L129.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
(Z)-1-(N-(2-aminoethyl)-N-(2-ammonioethyl)amino)diazen-1-ium-1,2-diolate 24 h exposure to 1 mM (Z)-1-(N-(2-aminoethyl)-N-(2-ammonioethyl)amino)diazen-1-ium-1,2-diolate leads to both reduction in cGKI expression and specific activity Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni2+-Sepharose column chromatography Sus scrofa

Source Tissue

Source Tissue Comment Organism Textmining
pulmonary artery
-
 Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + RKISASEFDRPLR
-
 Sus scrofa ADP + phosphorylated RKISASEFDRPLR
-
 ?

Synonyms

Synonyms Comment Organism
cGKI
-
 Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Sus scrofa
cGMP dependent, maximal activity at 0.1 mM Sus scrofa