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Literature summary for 2.7.11.12 extracted from

  • Qin, X.; Zheng, X.; Qi, H.; Dou, D.; Raj, J.U.; Gao, Y.
    cGMP-dependent protein kinase in regulation of basal tone and in nitroglycerin- and nitric-oxide-induced relaxation in porcine coronary artery (2007), Pflugers Arch., 454, 913-923.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cGMP
-
Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by the PKA-specific inhibitor myristoylated PKI Sus scrofa
Rp-8-Br-PET-cGMPS the PKG inhibitor has no effect in vivo on the basal tension of vessels treated with nitro-L-arginine, nitro-L-arginine plus indomethacin, or of vessels denuded of the endothelium, overview Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
x * 75000, PKG type I, SDS-PAGE Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Sus scrofa PKG is involved in the regulation of basal tension and plays a primary role in relaxation induced by nitrovasodilators, whereas PKA may play a minor role ?
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
PKG type I
-

Source Tissue

Source Tissue Comment Organism Textmining
coronary artery
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PKG is involved in the regulation of basal tension and plays a primary role in relaxation induced by nitrovasodilators, whereas PKA may play a minor role Sus scrofa ?
-
?

Subunits

Subunits Comment Organism
? x * 75000, PKG type I, SDS-PAGE Sus scrofa

Synonyms

Synonyms Comment Organism
PKG
-
Sus scrofa
PKG type I
-
Sus scrofa

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Sus scrofa

Cofactor

Cofactor Comment Organism Structure
ATP
-
Sus scrofa