Literature summary for 2.7.11.12 extracted from

Zhang, C.; Ondeyka, J.G.; Herath, K.B.; Guan, Z.; Collado, J.; Pelaez, F.; Leavitt, P.S.; Gurnett, A.; Nare, B.; Liberator, P.; Singh, S.B.
Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity (2006), J. Nat. Prod., 69, 710-712.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4-methoxy-3,6-diphenylcyclohexa-3,5-diene-1,2-dione	isolated from a microbial extract of a Phoma sp.	Eimeria tenella
4-methoxy-3,6-diphenylcyclohexa-3,5-diene-1,2-dione	isolated from a microbial extract of a Phoma sp.	Toxoplasma gondii
4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine	a synthetic compound	Eimeria tenella
4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine	a synthetic compound	Toxoplasma gondii
6'-methoxy-1,1':4',1''-terphenyl-2,2',5'-triol	isolated from a microbial extract of a Phoma sp.	Eimeria tenella
6'-methoxy-1,1':4',1''-terphenyl-2,2',5'-triol	isolated from a microbial extract of a Phoma sp.	Toxoplasma gondii
6'-methoxy-1,1':4',1''-terphenyl-2,2',5,5'-tetrol	isolated from a microbial extract of a Phoma sp.	Eimeria tenella
6'-methoxy-1,1':4',1''-terphenyl-2,2',5,5'-tetrol	isolated from a microbial extract of a Phoma sp.	Toxoplasma gondii
terferol	isolated from a microbial extract of a Phoma sp.	Eimeria tenella
terferol	isolated from a microbial extract of a Phoma sp.	Toxoplasma gondii

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Eimeria tenella
Mg2+	-	Toxoplasma gondii

Organism

Organism	UniProt	Comment	Textmining
Eimeria tenella	-	-	-
Toxoplasma gondii	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + a peptide	-	Eimeria tenella	ADP + a phosphorylated peptide	-	?
ATP + a peptide	-	Toxoplasma gondii	ADP + a phosphorylated peptide	-	?

Synonyms

Synonyms	Comment	Organism
PKG	-	Eimeria tenella
PKG	-	Toxoplasma gondii

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Eimeria tenella
ATP	-	Toxoplasma gondii

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.000001	-	-	Eimeria tenella	4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine
0.00021	-	-	Toxoplasma gondii	4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine
0.0009	-	-	Eimeria tenella	4-methoxy-3,6-diphenylcyclohexa-3,5-diene-1,2-dione
0.0039	-	-	Eimeria tenella	terferol
0.0052	-	-	Eimeria tenella	6'-methoxy-1,1':4',1''-terphenyl-2,2',5'-triol
0.0058	-	-	Eimeria tenella	6'-methoxy-1,1':4',1''-terphenyl-2,2',5,5'-tetrol
0.0095	-	-	Toxoplasma gondii	6'-methoxy-1,1':4',1''-terphenyl-2,2',5,5'-tetrol
0.0104	-	-	Toxoplasma gondii	6'-methoxy-1,1':4',1''-terphenyl-2,2',5'-triol
0.0268	-	-	Toxoplasma gondii	terferol

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Release 2023.1 (January 2023)