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Literature summary for 2.7.11.12 extracted from

  • Das, A.; Smolenski, A.; Lohmann, S.M.; Kukreja, R.C.
    Cyclic GMP-dependent protein kinase Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte (2006), J. Biol. Chem., 281, 38644-38652.
    View publication on PubMed
Search for more literature for 2.7.11.12

Cloned(Commentary)

Cloned (Comment) Organism
adenoviral transfection of rat adult cardiomyocytes with the human isozyme PKGIalpha and its catalytically inactive mutant PKGIalphaK390A Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information overexpression of active PKGIalpha, but not of the inactive mutant K390A, increases of Akt and inhibits necrosis and apoptosis in cardiomyocytes, overview Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Akt Homo sapiens
-
 ADP + phosphorylated Akt
-
 ?
additional information Homo sapiens PKG Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozymes PKGIalpha and PKGIbeta
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Akt
-
 Homo sapiens ADP + phosphorylated Akt
-
 ?
ATP + Akt phosphorylation at Ser473 Homo sapiens ADP + phosphorylated Akt
-
 ?
additional information PKG Ialpha attenuates necrosis and apoptosis following ischemia/reoxygenation in adult cardiomyocyte, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
PKGIalpha
-
 Homo sapiens
PKGIbeta
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens