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Literature summary for 2.7.11.12 extracted from

  • Zeng, Y.; Zhuang, S.; Gloddek, J.; Tseng, C.C.; Boss, G.R.; Pilz, R.B.
    Regulation of cGMP-dependent protein kinase expression by Rho and Kruppel-like transcription factor-4 (2006), J. Biol. Chem., 281, 16951-16961.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
additional information Rac1 stimulates PKG I expression Rattus norvegicus

Protein Variants

Protein Variants Comment Organism
additional information siRNA-mediated down-regulation of RhoA derepresses PKG I expression Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information Rho and Krueppel-like transcription factor-4 KLF4, a bound nuclear protein, suppress PKG I expression requiring Sp1 consensus sequences in the PKG I promoter, suppression in a in a cell density-dependent manner Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus PKG I plays a major role in vascular homeostasis by mediating smooth muscle relaxation in response to nitric oxide, regulation of PKG I expression by Rho and Kruppel-like transcription factor-4, RhoA is involved in decreased PKG I levels in vascular smooth muscle cells found in some models of hypertension and vascular injury, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Source Tissue

Source Tissue Comment Organism Textmining
aorta
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 Rattus norvegicus
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CS54 cell pulmonary artery smooth muscle cell line Rattus norvegicus
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smooth muscle pulmonary artery Rattus norvegicus
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vascular cell
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PKG I plays a major role in vascular homeostasis by mediating smooth muscle relaxation in response to nitric oxide, regulation of PKG I expression by Rho and Kruppel-like transcription factor-4, RhoA is involved in decreased PKG I levels in vascular smooth muscle cells found in some models of hypertension and vascular injury, overview Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
PKG I
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 Rattus norvegicus