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Literature summary for 2.7.11.12 extracted from

  • Godfrey, E.W.; Longacher, M.; Neiswender, H.; Schwarte, R.C.; Browning, D.D.
    Guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the developing neuromuscular junction (2007), Dev. Biol., 307, 195-201.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cyclic GMP
-
 Bos taurus
cGMP
-
 Bos taurus

Cloned(Commentary)

Cloned (Comment) Organism
expression of PKGIalpha in transgenic Xenopus laevis embryos Bos taurus

Protein Variants

Protein Variants Comment Organism
additional information overexpression in Xenopus laevis of either guanylate cyclase or PKG in embryos increases acetylcholine receptor aggregate area by 60–170%, whereas expression of a dominant negative form of guanylate cyclase inhibits endogenous aggregation by 50%, overview Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Rp-8-pCPT-cGMPS
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
neuromuscular junction
-
 Bos taurus 31594
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Bos taurus guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the postsynaptic differentiation of developing neuromuscular junctions, molecular mechanism ?
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle cell embryonic Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information guanylate cyclase and cyclic GMP-dependent protein kinase regulate agrin signaling at the postsynaptic differentiation of developing neuromuscular junctions, molecular mechanism Bos taurus ?
-
 ?

Synonyms

Synonyms Comment Organism
cyclic GMP-dependent protein kinase
-
 Bos taurus
PKG
-
 Bos taurus