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Literature summary for 2.7.11.12 extracted from

  • Andoh, T.; Chiueh, C.C.; Chock, P.B.
    Cyclic GMP-dependent protein kinase regulates the expression of thioredoxin and thioredoxin peroxidase-1 during hormesis in response to oxidative stress-induced apoptosis (2003), J. Biol. Chem., 278, 885-890.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-Br-cGMP
-
 Homo sapiens
cGMP dependent on Homo sapiens
additional information NO induces the enzyme via increased cGMP production Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
6-anilino-5,8-quinolinedione
-
 Homo sapiens
7-nitroindazole
-
 Homo sapiens
Rp-8-pCPT-cGMPS PKG inhibitor Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens through its c-Myc-, AP-1- and PEA3-binding motifs the enzyme regulates the expression of thioredoxin and thioredoxin peroxidase-1 during hormesis in response to oxidative stress-induced apoptosis, the enzyme is involved in cell protection against apoptosis and lipid oxidation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
SH-SY5Y cell neuroblastoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information through its c-Myc-, AP-1- and PEA3-binding motifs the enzyme regulates the expression of thioredoxin and thioredoxin peroxidase-1 during hormesis in response to oxidative stress-induced apoptosis, the enzyme is involved in cell protection against apoptosis and lipid oxidation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
cyclic GMP-dependent protein kinase
-
 Homo sapiens