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Literature summary for 2.7.11.12 extracted from
- Cyclic GMP-dependent protein kinases in protozoa (2005), Front. Biosci., 10, 1229-1238.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 8-NBD-cGMP | i.e. 8-[[2-[(7-nitro-4-benzofurazanyl)amino]ethyl]thio]guanosine-3',5'-cyclic monophosphate, poor, non-cooperative binding | Eimeria tenella |  |
| cGMP | - |
Chlamydomonas reinhardtii | |
| cGMP | - |
Homo sapiens | |
| cGMP | - |
Bos taurus | |
| cGMP | - |
Aplysia californica | |
| cGMP | - |
Caenorhabditis elegans | |
| cGMP | - |
Tetrahymena sp. | |
| cGMP | - |
Plasmodium yoelii | |
| cGMP | - |
Drosophila melanogaster | |
| cGMP | - |
Cryptosporidium parvum | |
| cGMP | - |
Eimeria maxima | |
| cGMP | - |
Hydra oligactis | |
| cGMP | - |
Apis mellifera | |
| cGMP | - |
Paramecium tetraurelia | |
| cGMP | binding site analysis, positive cooperativity at low concentration | Plasmodium falciparum | |
| cGMP | binding site analysis, positive cooperativity at low concentration | Paramecium tetraurelia | |
| cGMP | highly activating, binding site analysis | Toxoplasma gondii | |
| cGMP | highly activating, binding site analysis, cooperative binding | Eimeria tenella | |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | enzyme is a target for drug development | Eimeria tenella |
| drug development | enzyme is a target for drug development | Toxoplasma gondii |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of tagged enzyme in Escherichia coli, mutational analaysis, phylogenetic analysis | Plasmodium falciparum |
| expression of tagged enzyme in Escherichia coli, mutational analaysis, phylogenetic analysis | Paramecium tetraurelia |
| phylogenetic analysis | Chlamydomonas reinhardtii |
| phylogenetic analysis | Aplysia californica |
| phylogenetic analysis | Caenorhabditis elegans |
| phylogenetic analysis | Plasmodium yoelii |
| phylogenetic analysis | Drosophila melanogaster |
| phylogenetic analysis | Cryptosporidium parvum |
| phylogenetic analysis | Toxoplasma gondii |
| phylogenetic analysis | Eimeria maxima |
| phylogenetic analysis | Hydra oligactis |
| phylogenetic analysis | Apis mellifera |
| phylogenetic analysis, expression in Toxoplasma gondii | Eimeria tenella |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-[2-(fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine | inhibitor of apicomplexan parasite enzyme, IC50 is 1 nM for the enzyme of Eimeria tenella, mechanism | Eimeria tenella | |
| 4-[2-(fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine | inhibitor of apicomplexan parasite enzyme, mechanism | Toxoplasma gondii | |
| KT5926 | - |
Eimeria tenella | |
| KT5926 | - |
Toxoplasma gondii | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Apis mellifera | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Aplysia californica | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Bos taurus | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Caenorhabditis elegans | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Chlamydomonas reinhardtii | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Cryptosporidium parvum | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Drosophila melanogaster | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Eimeria maxima | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence ERKVQKAIKQQE | Eimeria tenella | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Homo sapiens | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Hydra oligactis | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence; the enzyme possesses an N-terminal autoinhibitory sequence ERNKKKAIFSND | Paramecium tetraurelia | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence ERNKKKAIFSND | Plasmodium falciparum | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Plasmodium yoelii | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Tetrahymena sp. | |
| additional information | the enzyme possesses an N-terminal autoinhibitory sequence | Toxoplasma gondii | |
| staurosporine | - |
Eimeria tenella | |
| staurosporine | - |
Toxoplasma gondii | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 113000 | 125000 | gel filtration | Eimeria tenella |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Apis mellifera | the enzyme is involved in age-dependent behavioural change from nurse to a foraging way of life by increased gene amfor expression | ? | - |
? | |
| additional information | Plasmodium falciparum | the enzyme is involved in cGMP-dependent male gametogenesis, i.e. exflagellation, together with Ca2+ release | ? | - |
? | |
| additional information | Paramecium tetraurelia | the enzyme is involved in cGMP-dependent male gametogenesis, i.e. exflagellation, together with Ca2+ release | ? | - |
? | |
| additional information | Eimeria tenella | the enzyme is involved in gliding motility and cell invasion | ? | - |
? | |
| additional information | Toxoplasma gondii | the enzyme is involved in gliding motility and cell invasion | ? | - |
? | |
| additional information | Drosophila melanogaster | the enzyme is involved in locomotion behaviour of the larvae in presence of food, so-called rover and sitter gene ecoding an isozyme termed forager, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Apis mellifera | Q8SSX4 | gene amfor | - |
| Aplysia californica | - |
- |
- |
| Bos taurus | - |
isozyme PKG-Ialpha | - |
| Caenorhabditis elegans | - |
- |
- |
| Chlamydomonas reinhardtii | - |
- |
- |
| Cryptosporidium parvum | Q8MMZ6 | - |
- |
| Drosophila melanogaster | P32023 | - |
- |
| Eimeria maxima | Q8MMZ5 | - |
- |
| Eimeria tenella | Q8MMZ8 | single gene encoded enzyme | - |
| Homo sapiens | - |
isozyme PKG-Ialpha | - |
| Hydra oligactis | O17474 | - |
- |
| Paramecium tetraurelia | Q869J9 | gene PKG-2 | - |
| Paramecium tetraurelia | Q869K0 | gene PKG-1 | - |
| Plasmodium falciparum | - |
- |
- |
| Plasmodium yoelii | - |
- |
- |
| Tetrahymena sp. | - |
- |
- |
| Toxoplasma gondii | Q8MMP4 | - |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| phosphoprotein | autophosphorylation | Chlamydomonas reinhardtii |
| phosphoprotein | autophosphorylation | Aplysia californica |
| phosphoprotein | autophosphorylation | Caenorhabditis elegans |
| phosphoprotein | autophosphorylation | Tetrahymena sp. |
| phosphoprotein | autophosphorylation | Plasmodium yoelii |
| phosphoprotein | autophosphorylation | Drosophila melanogaster |
| phosphoprotein | autophosphorylation | Eimeria tenella |
| phosphoprotein | autophosphorylation | Cryptosporidium parvum |
| phosphoprotein | autophosphorylation | Toxoplasma gondii |
| phosphoprotein | autophosphorylation | Eimeria maxima |
| phosphoprotein | autophosphorylation | Hydra oligactis |
| phosphoprotein | autophosphorylation | Apis mellifera |
| phosphoprotein | autophosphorylation | Paramecium tetraurelia |
| phosphoprotein | autophosphorylation of isozymes at a Thr in the catalytic domain is essential, phosphorylation sites, also for other kinases, overview | Homo sapiens |
| phosphoprotein | autophosphorylation of isozymes at a Thr in the catalytic domain is essential, phosphorylation sites, also for other kinases, overview | Bos taurus |
| phosphoprotein | autophosphorylation of isozymes, phosphorylation sites, also for other kinases, overview | Plasmodium falciparum |
| phosphoprotein | autophosphorylation of isozymes, phosphorylation sites, also for other kinases, overview | Paramecium tetraurelia |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| sporozoite | - |
Eimeria tenella | - |
| tachyzoite | - |
Toxoplasma gondii | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
the enzyme shows low basal activity | Eimeria tenella |
| additional information | - |
the enzyme shows low basal activity | Toxoplasma gondii |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | the enzyme is involved in age-dependent behavioural change from nurse to a foraging way of life by increased gene amfor expression | Apis mellifera | ? | - |
? | |
| additional information | the enzyme is involved in cGMP-dependent male gametogenesis, i.e. exflagellation, together with Ca2+ release | Plasmodium falciparum | ? | - |
? | |
| additional information | the enzyme is involved in cGMP-dependent male gametogenesis, i.e. exflagellation, together with Ca2+ release | Paramecium tetraurelia | ? | - |
? | |
| additional information | the enzyme is involved in gliding motility and cell invasion | Eimeria tenella | ? | - |
? | |
| additional information | the enzyme is involved in gliding motility and cell invasion | Toxoplasma gondii | ? | - |
? | |
| additional information | the enzyme is involved in locomotion behaviour of the larvae in presence of food, so-called rover and sitter gene ecoding an isozyme termed forager, overview | Drosophila melanogaster | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 113000-125000, functional enzyme, SDS-PAGE | Eimeria tenella |
| More | domain structure | Chlamydomonas reinhardtii |
| More | domain structure | Aplysia californica |
| More | domain structure | Caenorhabditis elegans |
| More | domain structure | Plasmodium falciparum |
| More | domain structure | Plasmodium yoelii |
| More | domain structure | Drosophila melanogaster |
| More | domain structure | Paramecium tetraurelia |
| More | domain structure | Eimeria tenella |
| More | domain structure | Cryptosporidium parvum |
| More | domain structure | Toxoplasma gondii |
| More | domain structure | Eimeria maxima |
| More | domain structure | Hydra oligactis |
| More | domain structure | Apis mellifera |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKG | - |
Chlamydomonas reinhardtii |
| PKG | - |
Homo sapiens |
| PKG | - |
Bos taurus |
| PKG | - |
Aplysia californica |
| PKG | - |
Caenorhabditis elegans |
| PKG | - |
Plasmodium falciparum |
| PKG | - |
Tetrahymena sp. |
| PKG | - |
Plasmodium yoelii |
| PKG | - |
Drosophila melanogaster |
| PKG | - |
Paramecium tetraurelia |
| PKG | - |
Eimeria tenella |
| PKG | - |
Cryptosporidium parvum |
| PKG | - |
Toxoplasma gondii |
| PKG | - |
Eimeria maxima |
| PKG | - |
Hydra oligactis |
| PKG | - |
Apis mellifera |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.000001 | - |
inhibitor of apicomplexan parasite enzyme, IC50 is 1 nM for the enzyme of Eimeria tenella, mechanism | Eimeria tenella | 4-[2-(fluorophenyl)-5-(1-methylpiperidine-4-yl)-1H-pyrrol-3-yl]pyridine | |
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