Activating Compound | Comment | Organism | Structure |
---|---|---|---|
8-pCPT-CGMP | i.e. 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate, 358% activation, inhibitor KT5823 abolishes the activating effect | Oryctolagus cuniculus | |
cAMP | crossactivation at high levels in vivo | Oryctolagus cuniculus | |
cGMP | - |
Oryctolagus cuniculus | |
forskolin | crossactivation at high levels above 0.001 mM in vivo | Oryctolagus cuniculus | |
isoproterenol | crossactivation at high levels above 0.001 mM in vivo | Oryctolagus cuniculus | |
sodium nitroprusside | i.e. SNP, selective activator of PKG, 414% activation, inhibitor KT5823 abolishes the activating effect | Oryctolagus cuniculus | |
Vasoactive intestinal peptide | i.e. VIP | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KT5823 | i.e. (8R,9S,11S)-(-)-9-methoxy-carbamyl-8-methyl-2,3,9,10-tetrahydro-8,11-epoxy-1H,8H-2,7b,11a-trizadizobenzo9(a,g)cycloocta(c,d,e)-trinden-1-one, selective PKG inhibitor | Oryctolagus cuniculus | |
additional information | no inhibition by myristoylated PKI14-22 amide | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + inositol 1,4,5-trisphosphate receptor-I | Oryctolagus cuniculus | the phosphorylation of the receptor inhibits inositol 1,4,5-trisphosphate-induced Ca2+ release | ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
isozymes PKG-Ialpha and PKG-Ibeta | - |
Purification (Comment) | Organism |
---|---|
isozyme PKG-Ialpha | Oryctolagus cuniculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
smooth muscle | gastric, primary | Oryctolagus cuniculus | - |
stomach | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + inositol 1,4,5-trisphosphate receptor-I | the phosphorylation of the receptor inhibits inositol 1,4,5-trisphosphate-induced Ca2+ release | Oryctolagus cuniculus | ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I | - |
? | |
ATP + inositol 1,4,5-trisphosphate receptor-I | selective phosphorylation at Ser1755 | Oryctolagus cuniculus | ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PKG | - |
Oryctolagus cuniculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
31 | - |
in vivo phosphorylation assay at | Oryctolagus cuniculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Oryctolagus cuniculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Oryctolagus cuniculus |