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Literature summary for 2.7.11.12 extracted from

  • Murthy, K.S.; Zhou, H.
    Selective phosphorylation of the IP3R-I in vivo by cGMP-dependent protein kinase in smooth muscle (2003), Am. J. Physiol. Gastronintest. Liver Physiol., 284, G221-230.
    View publication on PubMed
Search for more literature for 2.7.11.12

Activating Compound

Activating Compound Comment Organism Structure
8-pCPT-CGMP i.e. 8-(4-chlorophenylthio)guanosine 3',5'-cyclic monophosphate, 358% activation, inhibitor KT5823 abolishes the activating effect Oryctolagus cuniculus
cAMP crossactivation at high levels in vivo Oryctolagus cuniculus
cGMP
-
 Oryctolagus cuniculus
forskolin crossactivation at high levels above 0.001 mM in vivo Oryctolagus cuniculus
isoproterenol crossactivation at high levels above 0.001 mM in vivo Oryctolagus cuniculus
sodium nitroprusside i.e. SNP, selective activator of PKG, 414% activation, inhibitor KT5823 abolishes the activating effect Oryctolagus cuniculus
Vasoactive intestinal peptide i.e. VIP Oryctolagus cuniculus

Inhibitors

Inhibitors Comment Organism Structure
KT5823 i.e. (8R,9S,11S)-(-)-9-methoxy-carbamyl-8-methyl-2,3,9,10-tetrahydro-8,11-epoxy-1H,8H-2,7b,11a-trizadizobenzo9(a,g)cycloocta(c,d,e)-trinden-1-one, selective PKG inhibitor Oryctolagus cuniculus
additional information no inhibition by myristoylated PKI14-22 amide Oryctolagus cuniculus

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + inositol 1,4,5-trisphosphate receptor-I Oryctolagus cuniculus the phosphorylation of the receptor inhibits inositol 1,4,5-trisphosphate-induced Ca2+ release ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I
-
 ?

Organism

Organism UniProt Comment Textmining
Oryctolagus cuniculus
-
 isozymes PKG-Ialpha and PKG-Ibeta
-

Purification (Commentary)

Purification (Comment) Organism
isozyme PKG-Ialpha Oryctolagus cuniculus

Source Tissue

Source Tissue Comment Organism Textmining
smooth muscle gastric, primary Oryctolagus cuniculus
-
stomach
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + inositol 1,4,5-trisphosphate receptor-I the phosphorylation of the receptor inhibits inositol 1,4,5-trisphosphate-induced Ca2+ release Oryctolagus cuniculus ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I
-
 ?
ATP + inositol 1,4,5-trisphosphate receptor-I selective phosphorylation at Ser1755 Oryctolagus cuniculus ADP + phosphorylated inositol 1,4,5-trisphosphate receptor-I
-
 ?

Synonyms

Synonyms Comment Organism
PKG
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
31
-
 in vivo phosphorylation assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Oryctolagus cuniculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Oryctolagus cuniculus