Literature summary for 2.7.11.11 extracted from

Diering, S.; Stathopoulou, K.; Goetz, M.; Rathjens, L.; Harder, S.; Piasecki, A.; Raabe, J.; Schulz, S.; Brandt, M.; Pflaumenbaum, J.; Fuchs, U.; Donzelli, S.; Sadayappan, S.; Nikolaev, V.O.; Flenner, F.; Ehler, E.; Cuello, F.
Receptor-independent modulation of cAMP-dependent protein kinase and protein phosphatase signaling in cardiac myocytes by oxidizing agents (2020), J. Biol. Chem., 295, 15342-15365 .

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General Stability

General Stability	Organism
oxidation of PKA subunits occurs in intact cardiac myocytes	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P27791	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cardiac muscle fiber	-	Rattus norvegicus	-

Subunits

Subunits	Comment	Organism
heterotetramer	PKA is a heterotetrameric kinase comprising two regulatory and two catalytic subunits. Binding of two molecules of cAMP to each of the two regulatory subunits (PKA-R) induces the release of the active catalytic subunits (PKA-C)	Rattus norvegicus

Synonyms

Synonyms	Comment	Organism
PKA-C	-	Rattus norvegicus

General Information

General Information	Comment	Organism
metabolism	the contraction and relaxation of the heart is controlled by stimulation of the b1-adrenoreceptor (AR) signaling cascade, which leads to activation of cAMP-dependent protein kinase (PKA) and subsequent cardiac protein phosphorylation	Rattus norvegicus

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Release 2023.1 (January 2023)