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Literature summary for 2.7.11.11 extracted from

  • Komal, P.; Estakhr, J.; Kamran, M.; Renda, A.; Nashmi, R.
    cAMP-dependent protein kinase inhibits alpha7 nicotinic receptor activity in layer 1 cortical interneurons through activation of D1/D5 dopamine receptors (2015), J. Physiol., 593, 3513-3532.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
8-bromo-cAMP
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
KT-5720
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + alpha7 nicotinic acetylcholine receptor Homo sapiens phosphorylation at Ser365 ADP + phosphorylated alpha7 nicotinic acetylcholine receptor
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + alpha7 nicotinic acetylcholine receptor phosphorylation at Ser365 Homo sapiens ADP + phosphorylated alpha7 nicotinic acetylcholine receptor
-
 ?

Synonyms

Synonyms Comment Organism
PKA
-
 Homo sapiens
protein kinase A
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function dopamine receptor-mediated activation of protein kinase A negatively modulates nicotinic neurotransmission in prefrontal cortical interneurons, which may be a contributing mechanism of dopamine modulation of cognitive behaviours such as attention or working memory Homo sapiens