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Literature summary for 2.7.11.11 extracted from
- cAMP-dependent protein kinase regulates post-translational processing and expression of complex I subunits in mammalian cells (2010), Biochim. Biophys. Acta, 1797, 649-658.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| cAMP | - |
Mus musculus |  |
| cAMP | - |
Homo sapiens | |
| cAMP | - |
Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| H89 | a permeant inhibitor of PKA | Homo sapiens | |
| H89 | a permeant inhibitor of PKA | Mus musculus | |
| H89 | a permeant inhibitor of PKA | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Homo sapiens | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | - |
Homo sapiens | 5739 | - |
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| synapse | - |
Rattus norvegicus | 45202 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + CREB protein | Mus musculus | - |
ADP + CREB phosphoprotein | - |
? | |
| ATP + CREB protein | Rattus norvegicus | in brain synapses | ADP + CREB phosphoprotein | - |
? | |
| ATP + CREB protein | Mus musculus BALB/c | - |
ADP + CREB phosphoprotein | - |
? | |
| ATP + NDUFS4 subunit of complex I | Mus musculus | complex I is the NADH-ubiquinone oxidoreductase, E.C 1.6.5.3 | ADP + phosphorylated NDUFS4 subunit of complex I | - |
? | |
| ATP + NDUFS4 subunit of complex I | Homo sapiens | complex I is the NADH-ubiquinone oxidoreductase, E.C 1.6.5.3 | ADP + phosphorylated NDUFS4 subunit of complex I | - |
? | |
| ATP + NDUFS4 subunit of complex I | Rattus norvegicus | complex I is the NADH-ubiquinone oxidoreductase, E.C 1.6.5.3 | ADP + phosphorylated NDUFS4 subunit of complex I | - |
? | |
| ATP + NDUFS4 subunit of complex I | Mus musculus BALB/c | complex I is the NADH-ubiquinone oxidoreductase, E.C 1.6.5.3 | ADP + phosphorylated NDUFS4 subunit of complex I | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Mus musculus BALB/c | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow cell | mesenchymal cell | Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| C2C12 cell | - |
Mus musculus | - |
| fibroblast | - |
Mus musculus | - |
| fibroblast | adut skin and NHDF neonatal human dermal fibroblasts | Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| neuronal cell | - |
Rattus norvegicus | - |
| NIH-3T3 cell | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + CREB protein | - |
Mus musculus | ADP + CREB phosphoprotein | - |
? | |
| ATP + CREB protein | - |
Rattus norvegicus | ADP + CREB phosphoprotein | - |
? | |
| ATP + CREB protein | in brain synapses | Rattus norvegicus | ADP + CREB phosphoprotein | - |
? | |
| ATP + CREB protein | - |
Mus musculus BALB/c | ADP + CREB phosphoprotein | - |
? | |
| ATP + NDUFS4 subunit of complex I | complex I is the NADH-ubiquinone oxidoreductase, E.C 1.6.5.3 | Mus musculus | ADP + phosphorylated NDUFS4 subunit of complex I | - |
? | |
| ATP + NDUFS4 subunit of complex I | complex I is the NADH-ubiquinone oxidoreductase, E.C 1.6.5.3 | Homo sapiens | ADP + phosphorylated NDUFS4 subunit of complex I | - |
? | |
| ATP + NDUFS4 subunit of complex I | complex I is the NADH-ubiquinone oxidoreductase, E.C 1.6.5.3 | Rattus norvegicus | ADP + phosphorylated NDUFS4 subunit of complex I | - |
? | |
| ATP + NDUFS4 subunit of complex I | complex I is the NADH-ubiquinone oxidoreductase, E.C 1.6.5.3 | Mus musculus BALB/c | ADP + phosphorylated NDUFS4 subunit of complex I | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Mus musculus | |
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| metabolism | CREB phosphorylation, by PKA and/or CaMKs, activates at nuclear and mitochondrial level a transcriptional regulatory cascade which promotes the concerted expression of nuclear and mitochondrial encoded subunits of complex I and other respiratory chain proteins. The post-translational cAMP/PKA stimulation of the catalytic activity of complex I, is evidently associated with stimulation of protein biosynthesis, which characterizes the G1 phase of the cell cycle, in which fibroblasts are re-introduced from the G0 phase by serum supplementation | Mus musculus |
| additional information | NDUFS4 mutations result in defective assembly of complex I with severe effects on the respiratory chain, mouse model NDUFS4 point mutations and phenotypes, overview | Homo sapiens |
| physiological function | the cAMP-dependent protein kinase regulates post-translational processing and expression of complex I subunits in mammalian cells, it promotes the activity of complex I and lowers reactive oxygen species level in mammalian cell cultures, overview. cAMP-dependent phosphorylation of the NDUFS4 subunit of the complex promotes the import in mitochondria of this nuclear encoded protein | Homo sapiens |
| physiological function | the cAMP-dependent protein kinase regulates post-translational processing and expression of complex I subunits in mammalian cells, it promotes the activity of complex I and lowers reactive oxygen species level in mammalian cell cultures, overview. cAMP-dependent phosphorylation of the NDUFS4 subunit of the complex promotes the import in mitochondria of this nuclear encoded protein | Rattus norvegicus |
| physiological function | the cAMP-dependent protein kinase, PKA, and the transcription factor CREB play a critical role in the biosynthesis of complex I subunits, and PKA also regulates post-translational processing and expression of complex I subunits in mammalian cells, it promotes the activity of complex I and lowers reactive oxygen species level in mammalian cell cultures, overview. cAMP-dependent phosphorylation of the NDUFS4 subunit of the complex promotes the import in mitochondria of this nuclear encoded protein | Mus musculus |
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