Literature summary for 2.7.11.11 extracted from

Farquhar, M.J.; Harris, H.J.; Diskar, M.; Jones, S.; Mee, C.J.; Nielsen, S.U.; Brimacombe, C.L.; Molina, S.; Toms, G.L.; Maurel, P.; Howl, J.; Herberg, F.W.; van Ijzendoorn, S.C.; Balfe, P.; McKeating, J.A.
Protein kinase A-dependent step(s) in hepatitis C virus entry and infectivity (2008), J. Virol., 82, 8797-8811.

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Activating Compound

Activating Compound	Comment	Organism	Structure
8-bromo-cAMP	-	Homo sapiens
forskolin	0.01 mM	Homo sapiens

Application

Application	Comment	Organism
medicine	hepatitis C virus infection activates PKA in a cAMP-dependent manner to promote virus release and transmission	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
adenosine 3',5'-cyclic phosphorothioate	-	Homo sapiens
H-89	0.01 mM	Homo sapiens
myristoylated protein kinase I (14-22) amide	specific PKA inhibitor	Homo sapiens
protein kinase inhibitor peptide	PKI	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Huh-7.5 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + Kemptide	-	Homo sapiens	ADP + Kemptide phosphate	-	?

Synonyms

Synonyms	Comment	Organism
PKA type II	-	Homo sapiens
protein kinase A type II	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens
cAMP	dependent	Homo sapiens

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Release 2023.1 (January 2023)