Literature summary for 2.7.11.11 extracted from

Kleiveland, C.R.; Kassem, M.; Lea, T.
Human mesenchymal stem cell proliferation is regulated by PGE2 through differential activation of cAMP-dependent protein kinase isoforms (2008), Exp. Cell Res., 314, 1831-1838.

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Activating Compound

Activating Compound	Comment	Organism	Structure
prostaglandin E2	0.05 mM induce activity by elevation of cAMP levels	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
H-89	PKA specific inhibitor	Homo sapiens
additional information	not inhibited by wortmannin	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
mesenchymal stem cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + glycogen synthase kinase 3beta	phosphorylation of glycogen synthase kinase 3beta is carried out by the PKA type II isoform	Homo sapiens	ADP + phosphorylated glycogen synthase kinase 3beta	-	?

Synonyms

Synonyms	Comment	Organism
PKA type I	isoform	Homo sapiens
PKA type II	isoform	Homo sapiens
protein kinase A	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens
cAMP	dependent	Homo sapiens

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Release 2023.1 (January 2023)