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Literature summary for 2.7.11.11 extracted from

  • Wojtal, K.A.; Hoekstra, D.; van Ijzendoorn, S.C.
    cAMP-dependent protein kinase A and the dynamics of epithelial cell surface domains: moving membranes to keep in shape (2008), Bioessays, 30, 146-155.
    View publication on PubMed
Search for more literature for 2.7.11.11

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK293 cells Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
centrosome
-
 Rattus norvegicus 5813
-
cytoskeleton
-
 Rattus norvegicus 5856
-
endoplasmic reticulum
-
 Rattus norvegicus 5783
-
Golgi apparatus
-
 Rattus norvegicus 5794
-
plasma membrane
-
 Rattus norvegicus 5886
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + low-density lipoprotein-related protein
-
 Rattus norvegicus ADP + phosphorylated low-density lipoprotein-related protein
-
 ?
ATP + syntaphilin
-
 Rattus norvegicus ADP + syntaphilin phosphate
-
 ?
ATP + tomosyn
-
 Rattus norvegicus ADP + tomosyn phosphate
-
 ?

Subunits

Subunits Comment Organism
tetramer consists of two regulatory and two catalytic subunits, the regulatory subunits of PKA bind to free catalytic subunits (alpha, beta, gamma, or PRkX) and their primary function appears to keep the catalytic subunits in an inactive state, two molecules of cAMP bind to each regulatory subunit of PKA and causes the subsequent release and activation of the catalytic subunits Rattus norvegicus

Synonyms

Synonyms Comment Organism
PKA
-
 Rattus norvegicus
protein kinase A
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Rattus norvegicus
cAMP dependent Rattus norvegicus