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Literature summary for 2.7.11.11 extracted from

  • Howe, A.K.; Baldor, L.C.; Hogan, B.P.
    Spatial regulation of the cAMP-dependent protein kinase during chemotactic cell migration (2005), Proc. Natl. Acad. Sci. USA, 102, 14320-14325.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.11.11

Inhibitors

Inhibitors Comment Organism Structure
additional information complete enzyme inhibition inhibits pseudopod formation and cell migration Homo sapiens
additional information complete enzyme inhibition inhibits pseudopod formation and cell migration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme plays a paradoxical role in cell motility facilitating and inhibiting actin cytoskeletal dynamics and cell migration, overview, the enzyme is regulated in a subcellular space during cell migration, regulatory subunits RII are enriched in protrusive cellular structures and pseudopodia formed during chemotaxis, anchoring of PKA inhibits pseudopod formation and cell migration, regulation of the process overview ?
-
 ?
additional information Rattus norvegicus the enzyme plays a paradoxical role in cell motility facilitating and inhibiting actin cytoskeletal dynamics and cell migration, overview, the enzyme is regulated in a subcellular space during cell migration, regulatory subunits RII are enriched in protrusive cellular structures and pseudopodia formed during chemotaxis, anchoring of PKA inhibits pseudopod formation and cell migration, regulation of the process overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
REF-52 cell embryonic fibroblast cell line Rattus norvegicus
-
WI-38 cell fetal lung fibroblast-like cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + protein tyrosine phosphatase i.e. PTP, contains a PEST motif Homo sapiens ADP + phosphorylated protein tyrosine phosphatase
-
 ?
ATP + protein tyrosine phosphatase i.e. PTP, contains a PEST motif Rattus norvegicus ADP + phosphorylated protein tyrosine phosphatase
-
 ?
ATP + VASP i.e. vasodilator-stimulated phosphoprotein Homo sapiens ADP + phosphorylated VASP
-
 ?
ATP + VASP i.e. vasodilator-stimulated phosphoprotein Rattus norvegicus ADP + phosphorylated VASP
-
 ?
additional information the enzyme plays a paradoxical role in cell motility facilitating and inhibiting actin cytoskeletal dynamics and cell migration, overview, the enzyme is regulated in a subcellular space during cell migration, regulatory subunits RII are enriched in protrusive cellular structures and pseudopodia formed during chemotaxis, anchoring of PKA inhibits pseudopod formation and cell migration, regulation of the process overview Homo sapiens ?
-
 ?
additional information the enzyme plays a paradoxical role in cell motility facilitating and inhibiting actin cytoskeletal dynamics and cell migration, overview, the enzyme is regulated in a subcellular space during cell migration, regulatory subunits RII are enriched in protrusive cellular structures and pseudopodia formed during chemotaxis, anchoring of PKA inhibits pseudopod formation and cell migration, regulation of the process overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
PKA
-
 Homo sapiens
PKA
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens
ATP
-
 Rattus norvegicus