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Literature summary for 2.7.11.11 extracted from
- Stimulation of beta-adrenoceptors inhibits store-operated channel currents via a cAMP-dependent protein kinase mechanism in rabbit portal vein myocytes (2005), J. Physiol., 562, 395-406.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 8-bromo-cAMP | - |
Oryctolagus cuniculus |  |
| cAMP | - |
Oryctolagus cuniculus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| H-89 | selective strong inhibitor | Oryctolagus cuniculus | |
| KT5720 | specific for PKA | Oryctolagus cuniculus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Oryctolagus cuniculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Oryctolagus cuniculus | activated PKA catalytic subunit C with cAMP or 8-bromo-cAMP, stimulated by beta1-adrenoreceptor activity, inhibits store-operated channel current activity in vascular tissue | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
New Zealand White rabbits, constitutive PKA | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| myocyte | portal vein smooth muscle myocyte | Oryctolagus cuniculus | - |
| portal vein | portal vein smooth muscle myocyte | Oryctolagus cuniculus | - |
| smooth muscle | portal vein smooth muscle myocyte | Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | activated PKA catalytic subunit C with cAMP or 8-bromo-cAMP, stimulated by beta1-adrenoreceptor activity, inhibits store-operated channel current activity in vascular tissue | Oryctolagus cuniculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PKA | - |
Oryctolagus cuniculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Oryctolagus cuniculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Oryctolagus cuniculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Oryctolagus cuniculus | |
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Release 2023.1 (January 2023)
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