Activating Compound | Comment | Organism | Structure |
---|---|---|---|
cAMP | dependent on, activates the enzyme by partly dissociating the regulatory and the catalytic subunits, determination and analysis of the mechanism, the substrate plays a differential role in activation of type I versus type II holoenzyme | Bos taurus |
Cloned (Comment) | Organism |
---|---|
distinct expression of catalytic subunit C, regulatory subunit RIalpha, and regulatory subunit RIIbeta in Escherichia coli strain 222 | Bos taurus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate | activation mechanism | Bos taurus |
Renatured (Comment) | Organism |
---|---|
recombinant catalytic subunit C, regulatory subunit RIalpha, and regulatory subunit RIIbeta from Escherichia coli strain 222 by cAMP-affinity chromatography, gel filtration, and dialysis | Bos taurus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + Kemptide | catalytic subunit C | Bos taurus | ADP + Kemptide phosphate | - |
? | |
additional information | substrates have differential effects on type I and type II PKA holoenzyme dissociation, the isolated catalytic subunit is catalytically active | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | substrates have differential effects on type I and type II PKA holoenzyme dissociation, X-ray scattering measurements, overview | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
protein kinase A | - |
Bos taurus |
type I PKA | - |
Bos taurus |
type II PKA | - |
Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Bos taurus |