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Literature summary for 2.7.11.10 extracted from

  • Zheng, J.; Park, M.H.; Lee, H.P.; Hyun, B.K.; Chun, H.O.; Jung, S.H.; Seo, H.O.; Ham, Y.W.; Han, S.B.; Hong, J.T.
    A small molecule, (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) phenol suppresses tumor growth via inhibition of IkappaB kinase beta in colorectal cancer in vivo and in vitro (2017), Oncotarget, 8, 91258-91269 .
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
C99S the mutation partially abolishes (E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol-induced cell growth inhibition and enhances expression of death receptors 5 and 6 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(E)-2-methoxy-4-(3-(4-methoxyphenyl)prop-1-en-1-yl)phenol the compound directly binds to the ATP binding site of the enzyme with a strong binding affinity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [IkappaB protein] Homo sapiens
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O14920
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CCD-18Co cell
-
 Homo sapiens
-
colorectal cancer cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
SW-480 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [IkappaB protein]
-
 Homo sapiens ADP + [IkappaB phosphoprotein]
-
 ?

Synonyms

Synonyms Comment Organism
IkappaB kinase beta
-
 Homo sapiens
IKKbeta
-
 Homo sapiens