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Literature summary for 2.7.11.10 extracted from

  • Gao, S.; Wu, J.; Liang, L.; Xu, R.
    RNF8 negatively regulates NF-kappaB signaling by targeting IkappaB kinase implications for the regulation of inflammation signaling (2017), Biochem. Biophys. Res. Commun., 488, 189-195 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ring finger protein 8 upon TNFalpha stimulation, ring finger protein 8 binds to the catalytic subunits of the enzyme complex, resulting in inhibition of IkappaB kinase alpha/beta phosphorylation and subsequent nuclear factor-kappaB activation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + NF-kappaB Homo sapiens
-
ADP + phosphorylated NF-kappaB
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
U2-OS cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + NF-kappaB
-
Homo sapiens ADP + phosphorylated NF-kappaB
-
?

Synonyms

Synonyms Comment Organism
IkappaB kinase
-
Homo sapiens
IKK
-
Homo sapiens