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Literature summary for 2.7.11.10 extracted from

  • Duncan, E.A.; Goetz, C.A.; Stein, S.J.; Mayo, K.J.; Skaggs, B.J.; Ziegelbauer, K.; Sawyers, C.L.; Baldwin, A.S.
    IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells (2008), Mol. Cancer Ther., 7, 391-397.
    View publication on PubMed
Search for more literature for 2.7.11.10

Application

Application Comment Organism
medicine inhibition of IkappaB kinase beta induces growth suppression and death in cells expressing wild-type, Imatinib-resistant, or the T315I Imatinib/Dasatinib-resistant forms of BCR-ABL Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + [IkappaB protein] Mus musculus
-
 ADP + [IkappaB phosphoprotein]
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
32D cell
-
 Mus musculus
-
BA/F3 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + [IkappaB protein]
-
 Mus musculus ADP + [IkappaB phosphoprotein]
-
 ?

Synonyms

Synonyms Comment Organism
IkappaB kinase beta
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Mus musculus

General Information

General Information Comment Organism
physiological function IkappaB kinase beta is a key upstream regulator of the NF-kappaB pathway Mus musculus