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Literature summary for 2.7.11.10 extracted from

  • Clark, K.; Plater, L.; Peggie, M.; Cohen, P.
    Use of the pharmacological inhibitor BX795 to study the regulation and physiological roles of TBK1 and IkappaB kinase epsilon: a distinct upstream kinase mediates Ser-172 phosphorylation and activation (2009), J. Biol. Chem., 284, 14136-14146.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
into the vector pSC-b for sequencing, subsequently into pCMV-FLAG-1 or pEBG6P Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
BX795
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q14164
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + interferon regulatory factor 3
-
 Homo sapiens ADP + phosphorylated interferon regulatory factor 3
-
 ?
ATP + STAT1 transcription factor
-
 Homo sapiens ADP + phosphorylated STAT1 transcription factor
-
 ?

Synonyms

Synonyms Comment Organism
IkappaB kinase epsilon
-
 Homo sapiens
IKKepsilon
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000041
-
-
 Homo sapiens BX795