Protein Variants | Comment | Organism |
---|---|---|
additional information | in cells infected with vaccina virus lacking gene B14R there is a higher level of phosphorylated IkappaBalpha but a similar level of IkappaBalpha compared to cells infected with control viruses expressing vaccina virus virulence factor B14, suggesting vaccina virus virulence factor B14 affects IKK activity | Homo sapiens |
additional information | in cells infected with vaccinia virus lacking gene B14R there is a higher level of phosphorylated IkappaBalpha but a similar level of IkappaBalpha compared to cells infected with control viruses expressing vaccinia virus virulence factor B14, suggesting vaccinia virus virulence factor B14 affects IKK activity | Homo sapiens |
S176E/S180E | vaccinia virus virulence factor B14 does inhibit a mutant containing a mutation in the activation loop. This suggests that phosphorylation of these serine residues in the activation loop of IKKbeta is targeted by B14 | Homo sapiens |
S177E/S181E | vaccina virus virulence factor B14 does not inhibit a mutant containing a mutation in the activation loop. This suggests that phosphorylation of these serine residues in the activation loop of IKKbeta is targeted by vaccina virus virulence factor B14 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
vaccina virus virulence factor B14 | interacts and inhibits IKKcomplex. Interaction between vaccina virus virulence factor B14 and IKK complex requires IKKbeta but not IKKalpha | Homo sapiens | |
vaccinia virus virulence factor B14 | interacts and inhibits IKKcomplex. Interaction between B14 and IKK complex requires IKKbeta but not IKKalpha | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | - |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + KKKKERLLDDRHDSGLDSMKDEE | IKK substrate peptide derived from IkappaBalpha sequence | Homo sapiens | ADP + phosphorylated-KKKKERLLDDRHDSGLDSMKDEE | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IkappaB kinase | - |
Homo sapiens |
IKKalpha | - |
Homo sapiens |
IKKbeta | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |