Protein Variants | Comment | Organism |
---|---|---|
additional information | analysis of IKKalpha and IKKbeta knockout cells shows that IKK alpha is the critical IKK subunit in controlling insulin-induced interaction with mTOR | Homo sapiens |
additional information | in HEK293 cells, knockdown of IKK alpha suppresses TNF-induced mTOR activation by greater that 50%, knockdown of IKKbeta has less of an effect | Homo sapiens |
additional information | using IKKbeta MCF7 knockout cells it is shown that in MCF7 cells TNF does not activate Akt and requires IKKbeta to activate mTOR | Mus musculus |
additional information | using siRNA to IKKalpha it is shown that IKKalpha is required for efficient induction of mTOR activation in response to insulin or TNF. Knockout of IKKalpha significantly reduces insulin- or TNF-induced activation | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15111 | - |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEK-293 cell | - |
Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
IKKalpha | - |
Mus musculus |
IKKalpha | - |
Homo sapiens |