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Literature summary for 2.7.11.10 extracted from

  • Cahill, C.M.; Rogers, J.T.
    Interleukin (IL) 1beta induction of IL-6 is mediated by a novel phosphatidylinositol 3-kinase-dependent AKT/IkappaB kinase alpha pathway targeting activator protein-1 (2008), J. Biol. Chem., 283, 25900-25912.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
T23A overexpression of a Ikappa B kinase alpha mutant, IKKalphaT23A, containing a mutation in a functional AKT phosphorylation site, completely abrogate IL-6 promoter activation in response to IL-1 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
LY294002 phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, but phosphorylation of Ser176/Ser180 is not Homo sapiens
Wortmannin phosphorylation of IKKalphaT23 is inhibited both by LY294002 and wortmannin, but phosphorylation of Ser176/Ser180 is not Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15111
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein IL-1 induces phosphorylation of IKKalpha on the NFkappaB inducing kinase (NIK) phosphorylation sites Ser176/Ser180 and on the Thr23 site Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + IkappaB alpha
-
Homo sapiens ADP + phosphorylated IkappaB alpha
-
?

Synonyms

Synonyms Comment Organism
IKKalpha
-
Homo sapiens