Literature summary for 2.7.11.10 extracted from

Karin, M.
The IkappaB kinase - a bridge between inflammation and cancer (2008), Cell Res., 18, 334-342.

Search for more literature for 2.7.11.10

Protein Variants

Protein Variants	Comment	Organism
additional information	gene disruption via homologous recombination reveals that activation of NF-kappaB in response to pathogen associated molecular patterns (PAMPs) and pro-inflammatory cytokines is dependent on IKKgamma/NEMO and on IKKbeta	Mus musculus
additional information	gene disruption via homologous recombination reveals that IKKalpha, but not IKKbeta, kinase activity is required for activation of an alternative NF-kappaB signaling pathway based on processing of NF-kappaB2/p100:RelB complexes to NF-kappaB2/p52:RelB dimers. In addition, IKKalpha, and not IKKbeta, is required for differentiation of stratified epithelia, such as the epidermis, but this function does not require its protein kinase activity	Mus musculus
additional information	Ikkalpha knockin mice are generated in which the two serine phosphoacceptor sites responsible for kinase activation are replaced with alanines. These mice express normal amounts of an IKKalpha protein whose kinase activity cannot be turned on in response to upstream stimuli. TRAMP mice, a mouse model for prostate carcinoma, that are rendered homozygous for the Ikkalpha knockin mutation are found to exhibit decelerated tumor development but eventually all died of primary prostate carcinoma. Knockin mice are found to display much fewer secondary site metastases than wild-type/TRAMP mice, indicating that IKK alpha is an enhancer for prostate metastasis	Mus musculus
additional information	mice lacking the IKKbeta gene in hepatocytes surprisingly show many more and faster growing chemically-induced hepatocellular carcinoma, indicating that in hepatocytes IKKbeta inhibits chemically-induced hepatocellular carcinoma	Mus musculus
additional information	targeted gene disruption of IKKbeta in intestinal epithelial cells leads to a 80% decline of colitis-associated cancer (CAC) induced by azoxymethane or dextran sulfate sodium salt administration	Mus musculus
additional information	targeted gene disruption of IKKbeta in mature macrophages and neutrophils leads to a 50% decrease of tumor multiplicity of colitis-associated cancer (CAC) induced by azoxymethane or dextran sulfate sodium salt administration	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	O88351	-	-
Mus musculus	Q60680	-	-

Synonyms

Synonyms	Comment	Organism
IKKalpha	-	Mus musculus
IKKbeta	-	Mus musculus

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Release 2023.1 (January 2023)