Any feedback?
Literature summary for 2.7.11.10 extracted from
- Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10 (2007), Proc. Natl. Acad. Sci. USA, 104, 908-913.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | Bcl10 degradation depends on NEMO and CARMA1 | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Bcl10 | Homo sapiens | negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview | ADP + phosphorylated Bcl10 | - |
? | |
| ATP + IkappaBalpha | Homo sapiens | degradation of IkappaBalpha | ADP + phosphorylated IkappaBalpha | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ATP + Bcl | Bcl10 is phosphorylated by the NEMO/IKK complex, recombinant substrate GST-Bcl10 expressed in HEK-293T cells, degradation of Bcl | Homo sapiens | ADP + phosphorylated Bcl10 | - |
? | |
| ATP + Bcl10 | negative regulatory activity of the IKK complex in Bcl10 degradation, which is part of the regulatory mechanisms that precisely control the response to antigens, overview | Homo sapiens | ADP + phosphorylated Bcl10 | - |
? | |
| ATP + IkappaBalpha | degradation of IkappaBalpha | Homo sapiens | ADP + phosphorylated IkappaBalpha | - |
? | |
| additional information | no activity with Rip2 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IkappaB kinase | - |
Homo sapiens |
| IKKbeta | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
